Home › Drug Codes › CPT Codes › 90375 · HYPERRAB
Updated July 1st, 2026

HYPERRAB CPT Drug Code: 90375

Rabies immune globulin (RIg), human, for intramuscular and/or subcutaneous use

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Q4 2026 Medicare Payment Limit for 90375, effective October 1, 2026: $276.043 per HCPCS billing unit, down 1.8% from $281.185. From CMS's final file.

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Medicare Payment Limit ?
$281.185
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$281.185
/ HCPCS billing unit · APC 9133
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
6
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Drug & Product Overview

HCPCS Descriptor Rabies immune globulin (RIg), human, for intramuscular and/or subcutaneous use
Manufacturer Grifols
Route of Administration Infiltration, Intramuscular
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About HYPERRAB

Hyperrab is a medication aligned to the HCPCS CPT Drug Code: 90375 for billing, pricing, and reimbursement purposes in the United States. It is a Vaccine drug administered via the infiltration or intramuscular routes and manufactured by Grifols.

According to CMS Drug Use Information: This medication is used to prevent a certain serious virus infection, rabies, in people who have been exposed to this virus under certain conditions (such as a bite wound or non-bite wound by an infected animal). This medication is made from healthy human blood that has high levels of certain defensive substances (antibodies) that help fight rabies infection.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 3 of 6 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
13533-0318-01 HyperRAB GRIFOLS USA, LLC 2 HyperRAB Infiltration Injection 300 UN… Login for More
13533-0318-03 HyperRAB GRIFOLS USA, LLC 6 HyperRAB Infiltration Injection 900 UN… Login for More
13533-0318-05 HyperRAB GRIFOLS USA, LLC 10 HyperRAB Infiltration Injection 1500 U… Login for More
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HYPERRAB
HYPERRAB
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HYPERRAB Pricing & Reimbursement

90375 Private Payer Reimbursement
$458.97 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

HYPERRAB CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
Not on the CMS JW / JZ list

CMS does not include Hyperrab (90375) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing 90375. Wastage billing guide →

HYPERRAB Medically Unlikely Edits (MUE)

The most billing units of 90375 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 150 iu.

Practitioner Office & Hospital Outpatient
20 units / day
= 3,000 iu per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

iu Enter a dose to see how many billing units it is and whether it is under the limit.

HYPERRAB Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Postexposure prophylaxis for rabies

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Frequently Asked Questions

Is there an available Hyperrab billing and coding guide?
Billing and coding information for HYPERRAB can be found through Grifols. Visit Here →
Are there any available Hyperrab patient assistance programs?
HYPERRAB patient assistance information can be found through Grifols. Visit Here →
Where can I find Hyperrab prescribing information?
HYPERRAB prescribing information can be found at the link below: Visit Here →
Where can I find Hyperrab side effect information?
Our team has not yet identified a source of side effects information for HYPERRAB. Please check back in a few weeks.
Does billing HYPERRAB require JZ/JW wastage modifiers?
CMS does not include HYPERRAB (90375) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing 90375. For more information, visit the link below.

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