EYLEA J Code: J0178

Drug & Product Overview

HCPCS Descriptor Injection, aflibercept, 1 mg

HCPCS Added Date January 1, 2013

Manufacturer Regeneron Pharmaceuticals

Route of Administration Intravitreal

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About EYLEA

Eylea is a medication aligned to the HCPCS J Code: J0178 for billing, pricing, and reimbursement purposes in the United States. It is an Ophthalmology drug administered via the intravitreal route and manufactured by Regeneron Pharmaceuticals.

According to CMS Drug Use Information: Aflibercept is used to treat certain serious eye conditions (such as macular edema/degeneration, diabetic retinopathy, retinopathy of prematurity). This medication can help preserve vision and prevent blindness. Aflibercept belongs to a class of drugs known as growth factor inhibitors. It works by slowing the growth of abnormal new blood vessels in the eye and decreasing leakage from these blood vessels. This monograph is about the following aflibercept products: aflibercept, aflibercept-ayyh.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
61755-0005-01	Eylea	Regeneron Pharmaceuticals, Inc.	2	2 MG / 0.05 ML
61755-0005-02	Eylea	Regeneron Pharmaceuticals, Inc.	2	2 MG / 0.05 ML

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EYLEA Pricing & Reimbursement

J0178 Private Payer Reimbursement

$777.99 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Aflibercept Biosimilar Information:

EYLEA Approval Date: November 18, 2011

Product Name	HCPCS Code	Active Ingredient	BLA Type
Eylea	J0178	Aflibercept	351(a) Originator Product
Opuviz	Q5153	Aflibercept	351(k) Interchangeable
Yesafili	Q5155	Aflibercept	351(k) Interchangeable
Ahzantive	Q5150	Aflibercept	351(k) Biosimilar
Enzeevu	Q5149	Aflibercept	351(k) Biosimilar
Pavblu	Q5147	Aflibercept	351(k) Biosimilar
Eydenzelt	Q5170	Aflibercept	351(k) Biosimilar

EYLEA CPT Administration Codes

CPT Code	Description
67028	Intravitreal injection of a pharmacologic agent (separate procedure) 67028

JW / JZ modifiers apply

CMS has identified Eylea (J0178) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

EYLEA Medically Unlikely Edits (MUE)

The most billing units of J0178 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

4 units / day

= 4 mg per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

EYLEA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Diabetic Macular Edema (DME) Diabetic Retinopathy (DR) Macular Edema Following Retinal Vein Occlusion (RVO) Neovascular (Wet) Age-Related Macular Degeneration (AMD) Retinopathy of Prematurity (ROP)

Drug Class

Vascular Endothelial Growth Factor Inhibitor [EPC]Vascular Endothelial Growth Factor Inhibitors [MoA]

Frequently Asked Questions

Is there an available Eylea billing and coding guide?

Billing and coding information for EYLEA can be found through Regeneron. Visit Here →

Are there any available Eylea patient assistance programs?

EYLEA patient assistance information can be found through Regeneron. Visit Here →

Where can I find Eylea prescribing information?

EYLEA prescribing information can be found at the link below: Visit Here →

Where can I find Eylea side effect information?

Information regarding EYLEA's side effects can be found at MedlinePlus Visit Here →

Does billing EYLEA require JZ/JW wastage modifiers?

CMS has identified EYLEA(J0178) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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