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Updated October 1st, 2026

ENZEEVU Q Code: Q5149

Injection, aflibercept-abzv (enzeevu), biosimilar, 1 mg

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Medicare Payment Limit ?
Not published
CMS publishes none for Q4 2026
APC Payment Limit ?
Not published
CMS publishes none for Q4 2026
ASP ?
No current ASP
Not available for Q4 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
1
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Drug & Product Overview

HCPCS Descriptor Injection, aflibercept-abzv (enzeevu), biosimilar, 1 mg
HCPCS Added Date April 1, 2025
Manufacturer Sandoz
Route of Administration Intravitreal
Generic Status Single-Source; Branded
Dosage Form Injection, Solution

About ENZEEVU

Enzeevu is a medication aligned to the HCPCS Q Code: Q5149 for billing, pricing, and reimbursement purposes in the United States. Classified under Ophthalmology, it is administered via the intravitreal route and manufactured by Sandoz.

Manufacturers, reach out to us to add more information.

NDC Code Information

1 NDC package is crosswalked to Q5149. Package detail is available to logged-in subscribers.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
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ENZEEVU Pricing & Reimbursement

Q5149 Private Payer Reimbursement
$16.67 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Aflibercept Biosimilar Information:

ENZEEVU Approval Date: August 9, 2024

Product Name HCPCS Code Active Ingredient BLA Type
Eylea J0178 Aflibercept 351(a) Originator Product
Opuviz Q5153 Aflibercept 351(k) Interchangeable
Yesafili Q5155 Aflibercept 351(k) Interchangeable
Ahzantive Q5150 Aflibercept 351(k) Interchangeable
Enzeevu Q5149 Aflibercept 351(k) Interchangeable
Pavblu Q5147 Aflibercept 351(k) Interchangeable
Eydenzelt Q5170 Aflibercept 351(k) Biosimilar
One of 6 Eylea biosimilars FDA-approved since 2024 See each approval by month on the BuyandBill.com Pipeline calendar. Comes with Pro. Every aflibercept approval, month by month.
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ENZEEVU CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
67028 Intravitreal injection of a pharmacologic agent (separate procedure) 67028
Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

ENZEEVU Medically Unlikely Edits (MUE)

The most billing units of Q5149 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient
4 units / day
= 4 mg per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

ENZEEVU Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Neovascular (Wet) Age-Related Macular Degeneration (AMD) Macular Edema Following Retinal Vein Occlusion (RVO) Diabetic Macular Edema (DME) Diabetic Retinopathy (DR) Retinopathy of Prematurity (ROP)
Drug Class
Vascular Endothelial Growth Factor Inhibitor [EPC]Vascular Endothelial Growth Factor Inhibitors [MoA]

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Compare ENZEEVU with EYLEA and its biosimilars

  • ENZEEVU Q5149
  • EYLEA J0178
  • PAVBLU Q5147
  • YESAFILI Q5155
  • AHZANTIVE Q5150
  • OPUVIZ Q5153

ASP, the Medicare payment limit, WAC and AWP for all 6 drugs on one timeline, with 10+ years of monthly history.

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Frequently Asked Questions

Is there an available ENZEEVU billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for ENZEEVU.
Are there any available ENZEEVU patient assistance programs?
ENZEEVU patient assistance information can be found through Sandoz. Visit Here →
Where can I find ENZEEVU prescribing information?
ENZEEVU prescribing information can be found at the link below. Visit Here →
Where can I find ENZEEVU side effect information?
A link for ENZEEVU side effect information is not available.
Does billing ENZEEVU require JZ/JW wastage modifiers?
CMS does not include ENZEEVU (Q5149) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q5149. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.

Related Drug Codes

Explore billing, coding, and pricing for drugs related to ENZEEVU.

J0178EYLEAInjection, aflibercept, 1 mgRegeneron PharmaceuticalsAdded January 1, 2013J0177EYLEA HDInjection, aflibercept hd, 1 mgRegeneron PharmaceuticalsAdded April 1, 2024C9161EYLEA HDInjection, aflibercept hd, 1 mgRegeneron PharmaceuticalsAdded January 1, 2024Q5147PAVBLUInjection, aflibercept-ayyh (pavblu), biosimilar, 1 mgAmgenAdded April 1, 2025Q5155YESAFILIInjection, aflibercept-jbvf (yesafili), biosimilar, 1 mgBiocon BiologicsAdded October 1, 2025Q5150AHZANTIVEInjection, aflibercept-mrbb (ahzantive), biosimilar, 1 mgFormycon AGAdded April 1, 2025Q5153OPUVIZInjection, aflibercept-yszy (opuviz), biosimilar, 1 mgBiogen Inc.Added July 1, 2025Q5170EydenzeltInjection, aflibercept-boav (eydenzelt), biosimilar, 1 mgAdded July 1, 2026J2778LUCENTISInjection, ranibizumab, 0.1 mgGenentechAdded January 1, 2008J2779SUSVIMOInjection, ranibizumab, via intravitreal implant (susvimo), 0.1 mgGenentechAdded July 1, 2022

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