OPUVIZ Q Code: Q5153

Drug & Product Overview

HCPCS Descriptor Injection, aflibercept-yszy (opuviz), biosimilar, 1 mg

HCPCS Added Date July 1, 2025

Manufacturer Biogen Inc.

Generic Status Single-Source; Branded

About OPUVIZ

Opuviz is a medication aligned to the HCPCS Q Code: Q5153 for billing, pricing, and reimbursement purposes in the United States. It is an Ophthalmology drug manufactured by Biogen Inc.

Manufacturers, reach out to us to add more information.

NDC Code Information

No NDC packages are aligned to Q5153 in publicly available CMS files.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
No public NDC alignments

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OPUVIZ Pricing & Reimbursement

Q5153 Private Payer Reimbursement

$25.01 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Aflibercept Biosimilar Information:

OPUVIZ Approval Date: May 20, 2024

Product Name	HCPCS Code	Active Ingredient	BLA Type
Eylea	J0178	Aflibercept	351(a) Originator Product
Opuviz	Q5153	Aflibercept	351(k) Interchangeable
Yesafili	Q5155	Aflibercept	351(k) Interchangeable
Ahzantive	Q5150	Aflibercept	351(k) Biosimilar
Enzeevu	Q5149	Aflibercept	351(k) Biosimilar
Pavblu	Q5147	Aflibercept	351(k) Biosimilar
Eydenzelt	Q5170	Aflibercept	351(k) Biosimilar

OPUVIZ CPT Administration Codes

CPT Code	Description
67028	Intravitreal injection of a pharmacologic agent (separate procedure) 67028

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

OPUVIZ Medically Unlikely Edits (MUE)

The most billing units of Q5153 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

4 units / day

= 4 mg per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

OPUVIZ Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Neovascular (Wet) Age-Related Macular Degeneration (AMD) Macular Edema Following Retinal Vein Occlusion (RVO) Diabetic Macular Edema (DME) Diabetic Retinopathy (DR)

Frequently Asked Questions

Is there an available OPUVIZ billing and coding guide?

Our team has not identified a manufacturer-source of billing and coding information for OPUVIZ. Please reach out to our team if this is a mistake.

Are there any available OPUVIZ patient assistance programs?

Our team has not identified a source of patient assistance information for OPUVIZ. Please reach out to us if this is a mistake.

Where can I find OPUVIZ prescribing information?

OPUVIZ prescribing information can be found at the link below. Visit Here →

Where can I find OPUVIZ side effect information?

Side effect information for OPUVIZ can be found through MedlinePlus. Visit Here →

Does billing OPUVIZ require JZ/JW wastage modifiers?

CMS does not include OPUVIZ (Q5153) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q5153. For more information, visit the link below.

About BuyandBill.com:

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