EYLEA HD J Code: J0177

Drug & Product Overview

HCPCS Descriptor Injection, aflibercept hd, 1 mg

HCPCS Added Date April 1, 2024

Manufacturer Regeneron Pharmaceuticals, Inc

Route of Administration Intravitreal

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About EYLEA HD

Eylea HD is a medication aligned to the HCPCS J Code: J0177 for billing, pricing, and reimbursement purposes in the United States. This Ophthalmology medication is administered via the intravitreal route and manufactured by Regeneron Pharmaceuticals, Inc.

According to CMS Drug Use Information: Aflibercept is used to treat certain serious eye conditions (such as macular edema/degeneration, diabetic retinopathy, retinopathy of prematurity). This medication can help preserve vision and prevent blindness. Aflibercept belongs to a class of drugs known as growth factor inhibitors. It works by slowing the growth of abnormal new blood vessels in the eye and decreasing leakage from these blood vessels. This monograph is about the following aflibercept products: aflibercept, aflibercept-ayyh.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
61755-0050-01	Eylea Hd	Regeneron Pharmaceuticals, Inc	8	8 MG / 0.07 ML

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EYLEA HD Pricing & Reimbursement

J0177 Private Payer Reimbursement

$311.79 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Biosimilar Information

EYLEA HD Approval Date: August 18, 2023

Product Name	HCPCS Code	Active Ingredient	BLA Type
EYLEA HD	J0177	Aflibercept	351(a) Originator Product
EYLEA	J0178	Aflibercept	351(a) Originator Product
EYDENZELT	N/A	Aflibercept	351(K) Biosimilar
PAVBLU	Q5147	Aflibercept	351(K) Biosimilar
ENZEEVU	Q5149	Aflibercept	351(K) Biosimilar
AHZANTIVE	Q5150	Aflibercept	351(K) Biosimilar
OPUVIZ	Q5153	Aflibercept	351(K) Interchangeable
YESAFILI	Q5155	Aflibercept	351(K) Interchangeable

EYLEA HD CPT Administration Codes

CPT Code	Description
67028	Intravitreal injection of a pharmacologic agent (separate procedure) 67028

JW / JZ modifiers apply

CMS has identified Eylea HD (J0177) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

EYLEA HD Medically Unlikely Edits (MUE)

The most billing units of J0177 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

16 units / day

= 16 mg per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

EYLEA HD Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Diabetic Macular Edema (DME) Diabetic Retinopathy (DR) Macular Edema Following Retinal Vein Occlusion (RVO) Neovascular (Wet) Age-Related Macular Degeneration (nAMD)

Drug Class

Vascular Endothelial Growth Factor Inhibitor [EPC]Vascular Endothelial Growth Factor Inhibitors [MoA]

Frequently Asked Questions

Is a Eylea Hd billing and coding guide available?

Our team has not identified a manufacturer-published source of billing and coding information for EYLEA HD.

Is Eylea Hd patient assistance information available?

EYLEA HD patient assistance information can be found through Regeneron Pharmaceuticals Inc.. Visit Here →

Where can I find Eylea Hd prescribing information?

EYLEA HD prescribing information can be found at the link below: Visit Here →

Where can I find Eylea Hd side effect information?

Information regarding EYLEA HD's potential side effects can be found at MedlinePlus

Does billing EYLEA HD require JZ/JW wastage modifiers?

CMS has identified EYLEA HD(J0177) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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