LUCENTIS J Code: J2778

Drug & Product Overview

HCPCS Descriptor Injection, ranibizumab, 0.1 mg

HCPCS Added Date January 1, 2008

Manufacturer Genentech

Route of Administration Intravitreal

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About LUCENTIS

Lucentis is a medication aligned to the HCPCS J Code: J2778 for billing, pricing, and reimbursement purposes in the United States. This Ophthalmology medication is administered via the intravitreal route and manufactured by Genentech.

According to CMS Drug Use Information: This medication is used to treat certain serious eye conditions (such as age-related macular degeneration, macular edema, diabetic retinopathy). It is used to help prevent decreased vision and blindness. Ranibizumab works by slowing the growth of abnormal new blood vessels in the eye and decreasing leakage from these blood vessels. This monograph is about the following ranibizumab products: ranibizumab, ranibizumab-eqrn, ranibizumab-leyk, and ranibizumab-nuna.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
50242-0080-03	Lucentis	Genentech, Inc.	5	0.5 MG / 0.05 ML
50242-0082-03	Lucentis	Genentech, Inc.	3	0.3 MG / 0.05 ML

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LUCENTIS Pricing & Reimbursement

J2778 Private Payer Reimbursement

$72.31 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Ranibizumab Biosimilar Information:

LUCENTIS Approval Date: June 30, 2006

Product Name	HCPCS Code	Active Ingredient	BLA Type
Lucentis	J2778	Ranibizumab	351(a) Originator Product
Byooviz	Q5124	Ranibizumab	351(k) Interchangeable
Cimerli	Q5128	Ranibizumab	351(k) Interchangeable
Nufymco	Q5168	Ranibizumab	351(k) Interchangeable
Ranluspec	N/A	Ranibizumab	351(k) Interchangeable

LUCENTIS CPT Administration Codes

CPT Code	Description
67028	Intravitreal injection of a pharmacologic agent (separate procedure) 67028

JW / JZ modifiers apply

CMS has identified Lucentis (J2778) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

LUCENTIS Medically Unlikely Edits (MUE)

The most billing units of J2778 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg.

Practitioner Office & Hospital Outpatient

10 units / day

= 1 mg per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

LUCENTIS Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Diabetic Macular Edema (DME) Diabetic Retinopathy (DR) Macular Edema Following Retinal Vein Occlusion (RVO) Myopic Choroidal Neovascularization (mCNV) Neovascular (Wet) Age-Related Macular Degeneration (AMD)

Drug Class

Vascular Endothelial Growth Factor Inhibitor [EPC]Vascular Endothelial Growth Factor Inhibitors [MoA]

Frequently Asked Questions

Is there an available Lucentis billing and coding guide?

Billing and coding information for LUCENTIS can be found through Genentech. Visit Here →

Are there any available Lucentis patient assistance programs?

LUCENTIS patient assistance information can be found through Genentech. Visit Here →

Where can I find Lucentis prescribing information?

LUCENTIS prescribing information can be found at the link below: Visit Here →

Where can I find Lucentis side effect information?

Information regarding LUCENTIS's side effects can be found at MedlinePlus Visit Here →

Does billing LUCENTIS require JZ/JW wastage modifiers?

CMS has identified LUCENTIS(J2778) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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