EPYSQLI Q Code: Q5151

Drug & Product Overview

HCPCS Descriptor Injection, eculizumab-aagh (epysqli), biosimilar, 2 mg

HCPCS Added Date April 1, 2025

Manufacturer Teva

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About EPYSQLI

Epysqli is a medication aligned to the HCPCS Q Code: Q5151 for billing, pricing, and reimbursement purposes in the United States. It is an Immunology drug administered via the intravenous route and manufactured by Teva.

According to CMS Drug Use Information: This medication is used to treat a certain blood disorder (paroxysmal nocturnal hemoglobinuria). This disorder can cause a decrease in red blood cells (anemia). This medication helps to block the decrease in red blood cells and can improve the symptoms of anemia (such as tiredness, shortness of breath) and decrease the need for blood transfusions. This medication may also be used to treat a certain immune system disorder (atypical Hemolytic Uremic Syndrome). It helps to prevent blood clots caused by this disorder. Eculizumab is also used to treat a certain muscle condition (generalized Myasthenia Gravis). It may help to improve symptoms of this condition (such as difficulty swallowing, trouble breathing). Eculizumab is also used to treat a certain nervous system disorder that affects the spinal cord and eye nerve (neuromyelitis optica spectrum disorder). It may help to reduce the number of hospital stays due to the disease. This monograph is about the following eculizumab products: eculizumab, eculizumab-aagh, eculizumab-aeeb.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
51759-0208-13	Epysqli	Teva Pharmaceuticals USA, Inc.	150	300 MG / 30 ML

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EPYSQLI Pricing & Reimbursement

Q5151 Private Payer Reimbursement

$31.50 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Eculizumab Biosimilar Information:

EPYSQLI Approval Date: July 19, 2024

Product Name	HCPCS Code	Active Ingredient	BLA Type
Soliris	J1299	Eculizumab	351(a) Originator Product
Bkemv	Q5152	Eculizumab	351(k) Interchangeable
Epysqli	Q5151	Eculizumab	351(k) Interchangeable

EPYSQLI CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

EPYSQLI Medically Unlikely Edits (MUE)

The most billing units of Q5151 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 2 mg.

Practitioner Office & Hospital Outpatient

600 units / day

= 1,200 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

EPYSQLI Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Atypical Hemolytic Uremic Syndrome (aHUS) Generalized Myasthenia Gravis (gMG) Neuromyelitis Optica Spectrum Disorder (NMOSD) Paroxysmal Nocturnal Hemoglobinuria (PNH)

Drug Class

Complement Inhibitor [EPC]Complement Inhibitors [MoA]

Frequently Asked Questions

Is there a manufacturer-published billing and coding guide for Epysqli?

Billing and coding information for EPYSQLI can be found through TEVA PHARMACEUTICALS USA. Visit Here →

Are there any available patient assistance programs for Epysqli?

EPYSQLI patient assistance information can be found through TEVA PHARMACEUTICALS USA. Visit Here →

Where can I find Epysqli prescribing information?

Epysqli prescribing information can be found at the link below. Visit Here →

Is there available side effect information for Epysqli?

Side effect information for Epysqli can be found through Medline Plus at the link below. Visit Here →

Does billing EPYSQLI require JZ/JW wastage modifiers?

CMS does not include EPYSQLI (Q5151) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q5151. For more information, visit the link below.

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