UPLIZNA J Code: J1823

Drug & Product Overview

HCPCS Descriptor Injection, inebilizumab-cdon, 1 mg

HCPCS Added Date January 1, 2021

Manufacturer Amgen

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection

About UPLIZNA

Uplizna is a medication aligned to the HCPCS J Code: J1823 for billing, pricing, and reimbursement purposes in the United States. Classified under Neurology, it is administered via the intravenous route and manufactured by Amgen.

According to CMS Drug Use Information: This medication is used to treat a certain nervous system disorder that affects the eye (optic) nerve and spinal cord (neuromyelitis optica spectrum disorder-NMOSD). Inebilizumab is also used to treat a chronic immune condition (immunoglobulin G4 related disease-IgG4-RD) and a certain muscle condition (generalized myasthenia gravis). This medication belongs to a class of drugs known as monoclonal antibodies. It may help reduce swelling and decrease the risk of attacks.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 1 of 2 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
75987-0150-03	Uplizna	Horizon Therapeutics USA, Inc.	300	100 MG / 10 ML
•••••-••••-•• Log in to view	UPLIZNA

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UPLIZNA Pricing & Reimbursement

J1823 Private Payer Reimbursement

$495.41 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

UPLIZNA Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 33.54%

Avg. Days to File 8.2days

Avg. Days to Pay 28.1days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J1823 claims analytics on FocalPoint →

UPLIZNA CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Uplizna (J1823) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

UPLIZNA Medically Unlikely Edits (MUE)

The most billing units of J1823 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 300 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

UPLIZNA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Generalized Myasthenia Gravis (gMG) Immunoglobulin G4-Related Disease (IgG4-RD) Neuromyelitis Optica Spectrum Disorder (NMOSD)

Drug Class

CD19-directed Antibody Interactions [MoA]CD19-directed Cytolytic Antibody [EPC]

Frequently Asked Questions

Is there an available Uplizna billing and coding guide?

Billing and coding information for UPLIZNA can be found through Amgen. Visit Here →

Are there any available Uplizna patient assistance programs?

UPLIZNA patient assistance information can be found through Amgen. Visit Here →

Where can I find Uplizna prescribing information?

UPLIZNA prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Uplizna side effect information?

Our team has not yet identified a source of side effects information for UPLIZNA. Please check back in a few weeks.

Does billing UPLIZNA require JZ/JW wastage modifiers?

CMS has identified UPLIZNA(J1823) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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