VYVGART HYTRULO J Code: J9334

Drug & Product Overview

HCPCS Descriptor Injection, efgartigimod alfa, 2 mg and hyaluronidase-qvfc

HCPCS Added Date January 1, 2024

Manufacturer Argenx US

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About VYVGART HYTRULO

Vyvgart Hytrulo is a medication aligned to the HCPCS J Code: J9334 for billing, pricing, and reimbursement purposes in the United States. It is a Neurology drug administered via the subcutaneous route and manufactured by Argenx US.

According to CMS Drug Use Information: Efgartigimod alfa is used to treat a certain muscle condition (generalized myasthenia gravis). It may help to improve symptoms of muscle weakness. This medication is also used to treat a certain nerve disorder (chronic inflammatory demyelinating polyneuropathy-CIDP). Efgartigimod alfa may help slow down the worsening of weakness in the arms and legs. Hyaluronidase is used to help the body absorb efgartigimod alfa, which helps it work better. This monograph is about the following efgartigimod/hyaluronidase products: efgartigimod-fcab/hyaluronidase, efgartigimod-qvfc/hyaluronidase.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
73475-1221-01	Vyvgart Hytrulo	Argenx Us	500	1000 MG / 5 ML
73475-1221-04	Vyvgart Hytrulo	Argenx Us	2000	1000 MG / 5 ML
73475-3102-03	Vyvgart Hytrulo	Argenx Us	504	1008 MG / 5.6 ML

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VYVGART HYTRULO Pricing & Reimbursement

J9334 Private Payer Reimbursement

$34.35 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

VYVGART HYTRULO CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

JW / JZ modifiers apply

CMS has identified Vyvgart Hytrulo (J9334) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

VYVGART HYTRULO Medically Unlikely Edits (MUE)

The most billing units of J9334 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 2 mg.

Practitioner Office & Hospital Outpatient

504 units / day

= 1,008 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

VYVGART HYTRULO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Chronic inflammatory demyelinating polyneuropathy (CIDP) Generalized myasthenia gravis (gMG)

Drug Class

Endoglycosidase [EPC]Glycoside Hydrolases [CS]Neonatal Fc Receptor Blocker [EPC]Neonatal Fc Receptor Blockers [MoA]

Frequently Asked Questions

Is there an available Vyvgart Hytrulo billing and coding guide?

Billing and coding information for VYVGART HYTRULO can be found through Argenx US. Visit Here →

Are there any available Vyvgart Hytrulo patient assistance programs?

VYVGART HYTRULO patient assistance information can be found through Argenx US. Visit Here →

Where can I find Vyvgart Hytrulo prescribing information?

VYVGART HYTRULO prescribing information can be found at the link below: Visit Here →

Where can I find Vyvgart Hytrulo side effect information?

Our team has not yet identified a source of side effects information for VYVGART HYTRULO. Please check back in a few weeks.

Does billing VYVGART HYTRULO require JZ/JW wastage modifiers?

CMS has identified VYVGART HYTRULO(J9334) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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