Home › Drug Codes › J Codes › J2781 · SYFOVRE
Updated October 1st, 2026

SYFOVRE J Code: J2781

Injection, pegcetacoplan, intravitreal, 1 mg

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Medicare Payment Limit ?
$135.267
down 9.2% since Q3 2026
/ HCPCS billing unitQ3 2026: $148.944
APC Payment Limit ?
$135.267
down 9.2% since Q3 2026
/ HCPCS billing unitQ3 2026: $148.944
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
2
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Drug & Product Overview

HCPCS Descriptor Injection, pegcetacoplan, intravitreal, 1 mg
HCPCS Added Date October 1, 2023
Manufacturer Apellis Pharmaceuticals
Route of Administration Intravitreal
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About SYFOVRE

Syfovre is a medication aligned to the HCPCS J Code: J2781 for billing, pricing, and reimbursement purposes in the United States. This Ophthalmology medication is administered via the intravitreal route and manufactured by Apellis Pharmaceuticals.

According to CMS Drug Use Information: Pegcetacoplan is used to treat a certain serious eye condition (geographic atrophy). It may help to delay vision loss. Pegcetacoplan works by helping to block your immune system from destroying cells in your eye.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
73606-0020-01 Syfovre Apellis Pharmaceuticals, Inc. 15 15 MG / 0.1 ML
73606-0020-02 Syfovre Apellis Pharmaceuticals, Inc. 15 15 MG / 0.1 ML
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SYFOVRE Pricing & Reimbursement

J2781 Private Payer Reimbursement
$140.32 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q4 2026

SYFOVRE CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
67028 Intravitreal injection of a pharmacologic agent (separate procedure) 67028
JW / JZ modifiers apply

CMS has identified Syfovre (J2781) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

SYFOVRE Medically Unlikely Edits (MUE)

The most billing units of J2781 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient
30 units / day
= 30 mg per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

SYFOVRE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Geographic atrophy secondary to age-related macular degeneration
Drug Class
Complement Inhibitor [EPC]Complement Inhibitors [MoA]

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Compare SYFOVRE with same-ingredient drugs

  • SYFOVRE J2781
  • SYFOVRE C9151

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Frequently Asked Questions

Is there an available Syfovre billing and coding guide?
Billing and coding information for SYFOVRE can be found through APELLIS PHARMACEUTICALS. Visit Here →
Are there any available Syfovre patient assistance programs?
SYFOVRE patient assistance information can be found through APELLIS PHARMACEUTICALS. Visit Here →
Where can I find Syfovre prescribing information?
SYFOVRE prescribing information can be found at the link below: Visit Here →
Where can I find Syfovre side effect information?
Our team has not yet identified a source of side effects information for SYFOVRE. Please check back in a few weeks.
Does billing SYFOVRE require JZ/JW wastage modifiers?
CMS has identified SYFOVRE(J2781) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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Related Drug Codes

Explore billing, coding, and pricing for drugs related to SYFOVRE.

C9151SYFOVREInjection, pegcetacoplan, 1 mgApellis PharmaceuticalsAdded July 1, 2023J2782IZERVAYInjection, avacincaptad pegol, 0.1 mgAstellas PharmaAdded April 1, 2024J1299SOLIRISInjection, eculizumab, 2 mgAstraZenecaAdded April 1, 2025J1303ULTOMIRISInjection, ravulizumab-cwvz, 10 mgAstraZenecaAdded October 1, 2019J9376VeopozInjection, pozelimab-bbfg, 1 mgRegeneron PharmaceuticalsAdded April 1, 2024Q5151EPYSQLIInjection, eculizumab-aagh (epysqli), biosimilar, 2 mgTevaAdded April 1, 2025Q5152BKEMVInjection, eculizumab-aeeb (bkemv), biosimilar, 2 mgAmgenAdded April 1, 2025C9161EYLEA HDInjection, aflibercept hd, 1 mgRegeneron PharmaceuticalsAdded January 1, 2024C9162IZERVAYInjection, avacincaptad pegol, 0.1 mgAstellas PharmaAdded January 1, 2024J0177EYLEA HDInjection, aflibercept hd, 1 mgRegeneron PharmaceuticalsAdded April 1, 2024

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