DIPHENHYDRAMINE HCL J Code: J1200
Injection, diphenhydramine hcl, up to 50 mg
Q4 2026 Medicare Payment Limit for J1200, effective October 1, 2026: $0.855 per HCPCS billing unit, up 13.7% from $0.752. From CMS's final file.
Drug & Product Overview
About DIPHENHYDRAMINE HCL
Diphenhydramine HCL is a medication aligned to the HCPCS J Code: J1200 for billing, pricing, and reimbursement purposes in the United States. This Antihistamine medication is administered via the intramuscular or intravenous routes and manufactured by multiple companies.
According to CMS Drug Use Information: Diphenhydramine injection is an antihistamine used to treat life-threatening allergic reactions (anaphylaxis) along with epinephrine and other treatments. It is also used to relieve symptoms of household allergies, hay fever and the common cold when medication cannot be given by mouth. Common allergy symptoms relieved by antihistamines include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose and sneezing. It is also used to treat nausea, vomiting and dizziness caused by motion sickness when medication cannot be given by mouth. Diphenhydramine works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine). Diphenhydramine should not be used in newborns or premature infants because of an increased risk of side effects. It should not be used for common cold symptoms in children less than 6 years of age due to the risk of serious side effects, such as slow/shallow breathing. Cough-and-cold products have not been shown to be safe or effective in children younger than 6.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 15 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00641-0376-25 | Diphenhydramine Hydrochloride | Hikma Pharmaceuticals USA Inc. | 25 | 50 MG / 1 ML |
| 23155-0263-31 | Diphenhydramine Hydrochloride | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 10 | 500 MG / 10 ML |
| 25021-0481-01 | Diphenhydramine Hydrochloride | Sagent Pharmaceuticals | 25 | 50 MG / 1 ML |
| 50090-0878-00 | Diphenhydramine Hydrochloride | A-S Medication Solutions | 1 | 2500 MG / 50 ML |
| 63323-0664-01 | Diphenhydramine | Fresenius Kabi USA, LLC | 25 | 50 MG / 1 ML |
| •••••-••••-•• Log in to view | DIPHENHYDRAMINE HCL | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | DIPHENHYDRAMINE HCL | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | DIPHENHYDRAMINE HCL | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
DIPHENHYDRAMINE HCL Pricing & Reimbursement
National median reimbursement across major commercial payers.
Create an account on PayerPrice for more information →Historical Graphing and Billing Calculator
Log in to calculate billing and reimbursement with live ASP, WAC & AWP pricing.
Login to use the calculator →DIPHENHYDRAMINE HCL CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
| 96374 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug |
CMS does not include Diphenhydramine HCL (J1200) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1200. Wastage billing guide →
DIPHENHYDRAMINE HCL Medically Unlikely Edits (MUE)
The most billing units of J1200 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
DIPHENHYDRAMINE HCL Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
Login for BuyandBill.com Analytics
Unlock deeper insights with BuyandBill’s Comparative Report!
- Compare ASP, WAC, and AWP across drugs.
- Visualize Drug Price Movement Over Time
- Tailor reports to drug class, manufacturer, or HCPCS Code.
- Compare Biosimilar and 505(b)(2) products.
Frequently Asked Questions
Is there an available Diphenhydramine Hcl billing and coding guide?
Are there any available Diphenhydramine Hcl patient assistance programs?
Where can I find Diphenhydramine Hcl prescribing information?
Where can I find Diphenhydramine Hcl side effect information?
Does billing DIPHENHYDRAMINE HCL require JZ/JW wastage modifiers?
About BuyandBill.com:
The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.
Related Drug Codes
Explore billing, coding, and pricing for drugs related to DIPHENHYDRAMINE HCL.