Home Drug Codes J Codes J1200 · DIPHENHYDRAMINE HCL
Updated July 1st, 2026

DIPHENHYDRAMINE HCL J Code: J1200

Injection, diphenhydramine hcl, up to 50 mg

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Q4 2026 Medicare Payment Limit for J1200, effective October 1, 2026: $0.855 per HCPCS billing unit, up 13.7% from $0.752. From CMS's final file.

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Medicare Payment Limit ?
$0.752
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
15
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Drug & Product Overview

HCPCS Descriptor Injection, diphenhydramine hcl, up to 50 mg
HCPCS Added Date January 1, 1982
Manufacturer Multiple Manufacturers
Route of Administration Intramuscular, Intravenous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose, Multi-Dose
Dosage Form Injection | Injection, Solution

About DIPHENHYDRAMINE HCL

Diphenhydramine HCL is a medication aligned to the HCPCS J Code: J1200 for billing, pricing, and reimbursement purposes in the United States. This Antihistamine medication is administered via the intramuscular or intravenous routes and manufactured by multiple companies.

According to CMS Drug Use Information: Diphenhydramine injection is an antihistamine used to treat life-threatening allergic reactions (anaphylaxis) along with epinephrine and other treatments. It is also used to relieve symptoms of household allergies, hay fever and the common cold when medication cannot be given by mouth. Common allergy symptoms relieved by antihistamines include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose and sneezing. It is also used to treat nausea, vomiting and dizziness caused by motion sickness when medication cannot be given by mouth. Diphenhydramine works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine). Diphenhydramine should not be used in newborns or premature infants because of an increased risk of side effects. It should not be used for common cold symptoms in children less than 6 years of age due to the risk of serious side effects, such as slow/shallow breathing. Cough-and-cold products have not been shown to be safe or effective in children younger than 6.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 15 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00641-0376-25 Diphenhydramine Hydrochloride Hikma Pharmaceuticals USA Inc. 25 50 MG / 1 ML
23155-0263-31 Diphenhydramine Hydrochloride Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 10 500 MG / 10 ML
25021-0481-01 Diphenhydramine Hydrochloride Sagent Pharmaceuticals 25 50 MG / 1 ML
50090-0878-00 Diphenhydramine Hydrochloride A-S Medication Solutions 1 2500 MG / 50 ML
63323-0664-01 Diphenhydramine Fresenius Kabi USA, LLC 25 50 MG / 1 ML
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DIPHENHYDRAMINE HCL Pricing & Reimbursement

J1200 Private Payer Reimbursement
$0.88 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

DIPHENHYDRAMINE HCL CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
Not on the CMS JW / JZ list

CMS does not include Diphenhydramine HCL (J1200) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1200. Wastage billing guide →

DIPHENHYDRAMINE HCL Medically Unlikely Edits (MUE)

The most billing units of J1200 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mg.

Practitioner Office & Hospital Outpatient
8 units / day
= 400 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

DIPHENHYDRAMINE HCL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Allergic reactions Allergic reactions / Anaphylaxis / Uncomplicated allergic conditions Allergic reactions / Anaphylaxis adjunct / Uncomplicated allergic conditions Motion Sickness Motion sickness Parkinsonism
Drug Class
Histamine H1 Receptor Antagonists [MoA]Histamine-1 Receptor Antagonist [EPC]

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Frequently Asked Questions

Is there an available Diphenhydramine Hcl billing and coding guide?
We have not yet identified a manufacturer source of Diphenhydramine Hcl billing and coding information.
Are there any available Diphenhydramine Hcl patient assistance programs?
Our team did not identify a source for Diphenhydramine Hcl patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Diphenhydramine Hcl prescribing information?
Our team is still working to identify a prescribing information source for DIPHENHYDRAMINE HCL
Where can I find Diphenhydramine Hcl side effect information?
Our team has not yet identified a source of side effects information for DIPHENHYDRAMINE HCL. Please check back in a few weeks.
Does billing DIPHENHYDRAMINE HCL require JZ/JW wastage modifiers?
CMS does not include DIPHENHYDRAMINE HCL (J1200) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1200. For more information, visit the link below.

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