PHENERGAN J Code: J2550
Injection, promethazine hcl, up to 50 mg
Q4 2026 Medicare Payment Limit for J2550, effective October 1, 2026: $3.241 per HCPCS billing unit, down 10.9% from $3.639. From CMS's final file.
Drug & Product Overview
About PHENERGAN
Phenergan is a medication aligned to the HCPCS J Code: J2550 for billing, pricing, and reimbursement purposes in the United States. This Antihistamine medication is administered via the intramuscular or intravenous routes and manufactured by multiple companies.
According to CMS Drug Use Information: Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used with other medication to treat severe allergic reactions (anaphylaxis) and reactions to blood products. It may also be used to treat milder allergic reactions when you cannot take promethazine by mouth. It may also be used to help you feel sleepy/relaxed before and after surgery, during other procedures, or during labor and delivery. It may also be used to help certain opioid pain relievers (such as meperidine) work better. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain. This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing). See also Warning section.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 17 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00641-0928-25 | Promethazine Hydrochloride | Hikma Pharmaceuticals USA Inc. | 13 | 25 MG / 1 ML |
| 00641-0929-25 | Promethazine Hydrochloride | Hikma Pharmaceuticals USA Inc. | 25 | 50 MG / 1 ML |
| 00641-0948-35 | Promethazine Hydrochloride | Hikma Pharmaceuticals USA Inc. | 13 | 25 MG / 1 ML |
| 39822-5525-03 | Promethazine Hydrochloride | XGen Pharmaceuticals DJB, Inc. | 13 | 25 MG / 1 ML |
| 50090-0879-00 | Promethazine Hydrochloride | A-S Medication Solutions | 25 | 50 MG / 1 ML |
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PHENERGAN Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →PHENERGAN CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
| 96374 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug |
CMS does not include Phenergan (J2550) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2550. Wastage billing guide →
PHENERGAN Medically Unlikely Edits (MUE)
The most billing units of J2550 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
PHENERGAN Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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