Home › Drug Codes › J Codes › J3410 · Hydroxyzine Hcl
Updated October 1st, 2026

Hydroxyzine Hcl J Code: J3410

Injection, hydroxyzine hcl, up to 25 mg

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Medicare Payment Limit ?
$14.113
/ HCPCS billing unit
APC Payment Limit ?
Not published
CMS publishes none for Q4 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
3
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Drug & Product Overview

HCPCS Descriptor Injection, hydroxyzine hcl, up to 25 mg
HCPCS Added Date January 1, 1982
Manufacturer American Regent
Route of Administration Intramuscular
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About Hydroxyzine Hcl

Hydroxyzine Hcl is a medication aligned to the HCPCS J Code: J3410 for billing, pricing, and reimbursement purposes in the United States. Classified under Antihistamine, it is administered via the intramuscular route and manufactured by American Regent.

According to CMS Drug Use Information: Hydroxyzine is used for the short-term treatment of nervousness and tension that may occur with certain mental/mood disorders (such as anxiety, dementia). It is also used to help manage withdrawal symptoms (such as anxiety, agitation) in alcoholics. Other uses include helping to decrease anxiety and nausea before/after surgery or during childbirth or helping certain opioid pain relievers (such as meperidine) work better. Hydroxyzine belongs to a class of medications called antihistamines. It is thought to work by affecting certain natural substances (acetylcholine, serotonin) in your body or by acting directly on certain parts of the brain. Hydroxyzine also blocks a natural substance that your body makes during an allergic reaction (histamine).

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00517-4201-25 Hydroxyzine Hydrochloride American Regent, Inc. 25 25 MG / 1 ML
00517-5601-25 Hydroxyzine Hydrochloride American Regent, Inc. 50 50 MG / 1 ML
00517-5602-25 Hydroxyzine Hydrochloride American Regent, Inc. 100 100 MG / 2 ML
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Hydroxyzine Hcl Pricing & Reimbursement

J3410 Private Payer Reimbursement
$13.64 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q4 2026

Hydroxyzine Hcl CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
JW / JZ modifiers apply

CMS has identified Hydroxyzine Hcl (J3410) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

Hydroxyzine Hcl Medically Unlikely Edits (MUE)

The most billing units of J3410 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 25 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
8 units / day
= 200 mg per day
Hospital Outpatient
16 units / day
= 400 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

Hydroxyzine Hcl Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Nausea and vomiting Pre- and postoperative adjunctive medication Pre- and postpartum adjunctive therapy Psychiatric and emotional emergencies, including acute alcoholism
Drug Class
Antihistamine [EPC]Histamine Receptor Antagonists [MoA]

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Frequently Asked Questions

Is there an available Hydroxyzine Hcl billing and coding guide?
We have not yet identified a manufacturer source of Hydroxyzine Hcl billing and coding information.
Are there any available Hydroxyzine Hcl patient assistance programs?
Our team did not identify a source for Hydroxyzine Hcl patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Hydroxyzine Hcl prescribing information?
Hydroxyzine Hcl prescribing information can be found at the link below: Visit Here →
Where can I find Hydroxyzine Hcl side effect information?
Information regarding Hydroxyzine Hcl's side effects can be found at MedlinePlus Visit Here →
Does billing Hydroxyzine Hcl require JZ/JW wastage modifiers?
CMS has identified Hydroxyzine Hcl(J3410) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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