Home › Drug Codes › Q Codes › Q0169 · PROMETHAZINE HCL
Updated July 1st, 2026

PROMETHAZINE HCL Q Code: Q0169

Promethazine hydrochloride, 12.5 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen

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Medicare Payment Limit ?
Not published
CMS publishes none for Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
No current ASP
Not available for Q3 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
21
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Drug & Product Overview

HCPCS Descriptor Promethazine hydrochloride, 12.5 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen
HCPCS Added Date April 1, 1998
Manufacturer Multiple Manufacturers
Route of Administration Oral
Generic Status Multi-Source; Generic
Dosage Form Tablet

About PROMETHAZINE HCL

Promethazine HCL is a medication aligned to the HCPCS Q Code: Q0169 for billing, pricing, and reimbursement purposes in the United States. Classified under Antihistamine, it is administered via the oral route and manufactured by multiple companies.

Manufacturers, reach out to us to add more information.

NDC Code Information

21 NDC packages are crosswalked to Q0169. Package detail is available to logged-in subscribers.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
•••••-••••-•• Log in to view PROMETHAZINE HCL
PROMETHAZINE HCL
PROMETHAZINE HCL
PROMETHAZINE HCL
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PROMETHAZINE HCL Pricing & Reimbursement

Q0169 Private Payer Reimbursement
$0.07 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

PROMETHAZINE HCL Medically Unlikely Edits (MUE)

The most billing units of Q0169 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 12.5 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
0 units / day
Not payable in this setting
Hospital Outpatient
12 units / day
= 150 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.
Not on the CMS JW / JZ list

CMS does not include Promethazine HCL (Q0169) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q0169. Wastage billing guide →

PROMETHAZINE HCL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Allergic reactions to blood or plasma (transfusion reactions) Allergic rhinitis and allergic conditions Allergic transfusion reactions Motion sickness Nausea and vomiting Nausea and vomiting associated with surgery and anesthesia Postoperative sedation and adjunctive analgesia Preoperative and postoperative sedation Preoperative sedation Sedation
Drug Class
Phenothiazine [EPC]Phenothiazines [CS]

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Frequently Asked Questions

Is there an available Promethazine Hcl billing and coding guide?
We have not yet identified a manufacturer source of Promethazine Hcl billing and coding information.
Are there any available Promethazine Hcl patient assistance programs?
Our team did not identify a source for Promethazine Hcl patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Promethazine Hcl prescribing information?
PROMETHAZINE HCL prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →
Where can I find Promethazine Hcl side effect information?
Our team has not yet identified a source of side effects information for PROMETHAZINE HCL. Please check back in a few weeks.
Does billing PROMETHAZINE HCL require JZ/JW wastage modifiers?
CMS does not include PROMETHAZINE HCL (Q0169) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q0169. For more information, visit the link below.

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