BENZTROPINE MESYLATE J Code: J0515

Drug & Product Overview

HCPCS Descriptor Injection, benztropine mesylate, per 1 mg

HCPCS Added Date January 1, 1982

Manufacturer Multiple Manufacturers

Route of Administration Intramuscular, Intravenous

Generic Status Multi-Source; Generic

Dosage Form Injection | Injection, Solution

About BENZTROPINE MESYLATE

Benztropine Mesylate is a medication aligned to the HCPCS J Code: J0515 for billing, pricing, and reimbursement purposes in the United States. Classified under Neurology, it is administered via the intramuscular or intravenous routes and manufactured by multiple companies.

According to CMS Drug Use Information: Benztropine is used to treat symptoms of Parkinson's disease or involuntary movements due to the side effects of certain psychiatric drugs (antipsychotics such as chlorpromazine/haloperidol). Benztropine belongs to a class of medication called anticholinergics that work by blocking a certain natural substance (acetylcholine). This helps decrease muscle stiffness, sweating, and the production of saliva, and helps improve walking ability in people with Parkinson's disease. Anticholinergics can stop severe muscle spasms of the back, neck, and eyes that are sometimes caused by psychiatric drugs. It can also decrease other side effects such as muscle stiffness/rigidity (extrapyramidal signs-EPS). It is not helpful in treating movement problems caused by tardive dyskinesia and may worsen them. Benztropine should not be used by children younger than 3 years.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 3 of 6 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00143-9233-05	Benztropine Mesylate	Hikma Pharmaceuticals USA Inc.	10	2 MG / 2 ML
00143-9729-05	Benztropine Mesylate	Hikma Pharmaceuticals USA Inc.	10	2 MG / 2 ML
68382-0860-10	Benztropine Mesylate	Zydus Pharmaceuticals USA Inc.	10	2 MG / 2 ML
•••••-••••-•• Log in to view	BENZTROPINE MESYLATE
	BENZTROPINE MESYLATE
	BENZTROPINE MESYLATE

Login to view 3 more NDC packages View pricing, complete NDC-to-HCPCS alignments, and package details.

Login →

BENZTROPINE MESYLATE Pricing & Reimbursement

J0515 Private Payer Reimbursement

$14.31 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

BENZTROPINE MESYLATE CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
96374	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug

JW / JZ modifiers apply

CMS has identified Benztropine Mesylate (J0515) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

BENZTROPINE MESYLATE Medically Unlikely Edits (MUE)

The most billing units of J0515 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

3 units / day

= 3 mg per day

Hospital Outpatient

6 units / day

= 6 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

BENZTROPINE MESYLATE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Drug-Induced Extrapyramidal Disorders Parkinsonism Postencephalitic and Idiopathic Parkinsonism

Drug Class

Anticholinergic [EPC]Antihistamine [EPC]Cholinergic Antagonists [MoA]Histamine Receptor Antagonists [MoA]

Frequently Asked Questions

Is there an available Benztropine Mesylate billing and coding guide?

We have not yet identified a manufacturer source of Benztropine Mesylate billing and coding information.

Are there any available Benztropine Mesylate patient assistance programs?

Our team did not identify a source for Benztropine Mesylate patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Benztropine Mesylate prescribing information?

Our team is still working to identify a prescribing information source for BENZTROPINE MESYLATE

Where can I find Benztropine Mesylate side effect information?

Our team has not yet identified a source of side effects information for BENZTROPINE MESYLATE. Please check back in a few weeks.

Does billing BENZTROPINE MESYLATE require JZ/JW wastage modifiers?

CMS has identified BENZTROPINE MESYLATE(J0515) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.