CEREZYME J Code: J1786

Drug & Product Overview

HCPCS Descriptor Injection, imiglucerase, 10 units

HCPCS Added Date January 1, 2011

Manufacturer Genzyme

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About CEREZYME

Cerezyme is a medication aligned to the HCPCS J Code: J1786 for billing, pricing, and reimbursement purposes in the United States. It is an Enzyme Replacement Therapy drug administered via the intravenous route and manufactured by Genzyme.

According to CMS Drug Use Information: Imiglucerase is used to treat a certain rare genetic problem (Gaucher disease). Imiglucerase replaces a certain natural substance (an enzyme called glucocerebrosidase) that is missing in people with Gaucher disease. This medication improves blood, bone, liver, and spleen problems caused by Gaucher disease. Imiglucerase does not correct the genetic problem, and treatment must be continued for life.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
58468-4663-01	Cerezyme	Genzyme Corporation	40	Cerezyme Intravenous I njection 400 UNI… Login for More

Login for the full NDC crosswalk View pricing, complete NDC-to-HCPCS alignments, and package details.

Login →

CEREZYME Pricing & Reimbursement

J1786 Private Payer Reimbursement

$43.37 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

CEREZYME CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Cerezyme (J1786) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

CEREZYME Medically Unlikely Edits (MUE)

The most billing units of J1786 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 units.

Practitioner Office & Hospital Outpatient

680 units / day

= 6,800 units per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

CEREZYME Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

non-CNS manifestations of Type 1 or Type 3 Gaucher disease

Drug Class

Glucosylceramidase [CS]Hydrolytic Lysosomal Glucocerebroside-specific Enzyme [EPC]

Frequently Asked Questions

Is there an available Cerezyme billing and coding guide?

Billing and coding information for CEREZYME can be found through Genzyme. Visit Here →

Are there any available Cerezyme patient assistance programs?

CEREZYME patient assistance information can be found through Genzyme. Visit Here →

Where can I find Cerezyme prescribing information?

CEREZYME prescribing information can be found at the link below: Visit Here →

Where can I find Cerezyme side effect information?

Our team has not yet identified a source of side effects information for CEREZYME. Please check back in a few weeks.

Does billing CEREZYME require JZ/JW wastage modifiers?

CMS has identified CEREZYME(J1786) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.