Home Drug Codes J Codes J2998 · RYPLAZIM
Updated July 1st, 2026

RYPLAZIM J Code: J2998

Injection, plasminogen, human-tvmh, 1 mg

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Medicare Payment Limit ?
Not published
CMS publishes none for Q3 2026
APC Payment Limit ?
$38.421
/ HCPCS billing unit · APC 9206
ASP ?
No current ASP
Not available for Q3 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
2
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Drug & Product Overview

HCPCS Descriptor Injection, plasminogen, human-tvmh, 1 mg
HCPCS Added Date July 1, 2022
Manufacturer Kedrion Biopharma
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Powder, Lyophilized, For Solution

About RYPLAZIM

Ryplazim is a medication aligned to the HCPCS J Code: J2998 for billing, pricing, and reimbursement purposes in the United States. It is a Hematology drug administered via the intravenous route and manufactured by Kedrion Biopharma.

Manufacturers, reach out to us to add more information.

NDC Code Information

2 NDC packages are crosswalked to J2998. Package detail is available to logged-in subscribers.

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RYPLAZIM Pricing & Reimbursement

J2998 Private Payer Reimbursement
$39.88 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

RYPLAZIM CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
Not on the CMS JW / JZ list

CMS does not include Ryplazim (J2998) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2998. Wastage billing guide →

RYPLAZIM Medically Unlikely Edits (MUE)

The most billing units of J2998 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient
1,032 units / day
= 1,032 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

RYPLAZIM Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

plasminogen deficiency type 1 (hypoplasminogenemia)

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Frequently Asked Questions

Is there an available Ryplazim billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for RYPLAZIM.
Are there any available Ryplazim patient assistance programs?
RYPLAZIM patient assistance information can be found through Kedrion Biopharma. Visit Here →
Where can I find Ryplazim prescribing information?
RYPLAZIM prescribing information can be found at the link below: Visit Here →
Where can I find Ryplazim side effect information?
Our team has not yet identified a source of side effects information for RYPLAZIM. Please check back in a few weeks.
Does billing RYPLAZIM require JZ/JW wastage modifiers?
CMS does not include RYPLAZIM (J2998) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2998. For more information, visit the link below.

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