RYTELO J Code: J0870

Drug & Product Overview

HCPCS Descriptor Injection, imetelstat, 1 mg

HCPCS Added Date January 1, 2025

Manufacturer Geron

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About RYTELO

Rytelo is a medication aligned to the HCPCS J Code: J0870 for billing, pricing, and reimbursement purposes in the United States. This Hematology medication is administered via the intravenous route and manufactured by Geron.

According to CMS Drug Use Information: This medication is used to treat anemia in patients with a group of blood/bone marrow disorders (myelodysplastic syndromes-MDS). Imetelstat works by slowing or stopping the growth of cancer cells. This effect may help reduce the need for blood transfusions.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
82959-0111-01	Rytelo	Geron Corporation	188	188 MG
82959-0112-01	Rytelo	Geron Corporation	47	47 MG

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RYTELO Pricing & Reimbursement

J0870 Private Payer Reimbursement

$58.23 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

RYTELO Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 14.09%

Avg. Days to File 10.9days

Avg. Days to Pay 29.1days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J0870 claims analytics on FocalPoint →

RYTELO CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

RYTELO Medically Unlikely Edits (MUE)

The most billing units of J0870 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

1,081 units / day

= 1,081 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

RYTELO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

myelodysplastic syndromes (MDS) with transfusion-dependent anemia

Drug Class

Oligonucleotide Telomerase Inhibitor [EPC]Oligonucleotide Telomerase Inhibitors [MoA]

Frequently Asked Questions

Is there an available RYTELO billing and coding guide?

Billing and coding information for RYTELO can be found through Geron. Visit Here →

What are the available RYTELO patient assistance programs?

RYTELO patient assistance information can be found through Geron Corporation at the following URL: https://www.rytelo.com/patient-support/ Visit Here →

Where can I find RYTELO prescribing information?

RYTELO prescribing information can be found at the link below. Visit Here →

Where can I find RYTELO side effect information?

RYTELO side effect information can be found through MedlinePlus at the link below.

Does billing RYTELO require JZ/JW wastage modifiers?

CMS does not include RYTELO (J0870) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0870. For more information, visit the link below.

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