PROTAMINE SULFATE J Code: J2720

Drug & Product Overview

HCPCS Descriptor Injection, protamine sulfate, per 10 mg

HCPCS Added Date January 1, 1982

Manufacturer Fresenius Kabi

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About PROTAMINE SULFATE

Protamine Sulfate is a medication aligned to the HCPCS J Code: J2720 for billing, pricing, and reimbursement purposes in the United States. Classified under Hematology, it is administered via the intravenous route and manufactured by Fresenius Kabi.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 6 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
63323-0229-05	Protamine Sulfate	Fresenius Kabi USA, LLC	125	50 MG / 5 ML
63323-0229-15	Protamine Sulfate	Fresenius Kabi USA, LLC	125	50 MG / 5 ML
63323-0229-30	Protamine Sulfate	Fresenius Kabi USA, LLC	25	250 MG / 25 ML
63323-0229-35	Protamine Sulfate	Fresenius Kabi USA, LLC	25	250 MG / 25 ML
63323-0229-94	Protamine Sulfate	Fresenius Kabi USA, LLC	125	50 MG / 5 ML
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PROTAMINE SULFATE Pricing & Reimbursement

J2720 Private Payer Reimbursement

$1.47 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

PROTAMINE SULFATE CPT Administration Codes

CPT Code	Description
96374	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug

JW / JZ modifiers apply

CMS has identified Protamine Sulfate (J2720) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

PROTAMINE SULFATE Medically Unlikely Edits (MUE)

The most billing units of J2720 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

5 units / day

= 50 mg per day

Hospital Outpatient

10 units / day

= 100 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

PROTAMINE SULFATE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

heparin overdosage

Drug Class

Heparin Binding Activity [MoA]Heparin Reversal Agent [EPC]Reversed Anticoagulation Activity [PE]

Frequently Asked Questions

Is there an available Protamine Sulfate billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for PROTAMINE SULFATE.

Are there any available Protamine Sulfate patient assistance programs?

PROTAMINE SULFATE patient assistance information can be found through Fresenius Kabi. Visit Here →

Where can I find Protamine Sulfate prescribing information?

PROTAMINE SULFATE prescribing information can be found at the link below: Visit Here →

Where can I find Protamine Sulfate side effect information?

Our team has not yet identified a source of side effects information for PROTAMINE SULFATE. Please check back in a few weeks.

Does billing PROTAMINE SULFATE require JZ/JW wastage modifiers?

CMS has identified PROTAMINE SULFATE(J2720) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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