Home › Drug Codes › CPT Codes › 90759 · PREHEVBRIO
Updated July 1st, 2026

PREHEVBRIO CPT Vaccine Code: 90759

Hepatitis B vaccine (HepB), 3-antigen (S, Pre-S1, Pre-S2), 10 mcg dosage, 3 dose schedule, for intramuscular use

Login to unlock all benchmarks
Medicare Payment Limit ?
Not published
Not on CMS's current vaccine price files
CDC Cost / Dose ?
$•••.••
Login to view
Private Sector Cost / Dose ?
$•••.••
Login to view
WAC · AWP ?
$•••.••
Login to view
NDCs Crosswalked ?
1
View NDC crosswalk →
Medicare Coverage CMS publishes no Medicare Part B payment limit for PREHEVBRIO. Vaccines given for routine prevention are generally covered under Medicare Part D rather than Part B.

Vaccine & Product Overview

HCPCS Descriptor Hepatitis B vaccine (HepB), 3-antigen (S, Pre-S1, Pre-S2), 10 mcg dosage, 3 dose schedule, for intramuscular use
Manufacturer VBI Vaccines
Route of Administration Intramuscular
Generic Status Single-Source; Branded
Dosage Type Single-Dose

About PREHEVBRIO

Prehevbrio is a medication aligned to the HCPCS CPT Drug Code: 90759 for billing, pricing, and reimbursement purposes in the United States. It is a Vaccine drug administered via the intramuscular route and manufactured by VBI Vaccines.

According to CMS Drug Use Information: This vaccine is used to help prevent hepatitis B. Hepatitis B infection can cause serious problems including liver failure, long-term hepatitis B infection, cirrhosis, and liver cancer. Vaccination is the best way to protect against this infection. This vaccine works by increasing the body's natural defense (immunity) against the virus. The vaccine is recommended for people of all ages, especially those at an increased risk of getting the infection. Those at an increased risk include health care personnel, lab workers who handle blood and patient specimens, police, fire and emergency medical personnel who give first aid treatment, hemophiliacs, dialysis patients, people who live with or spend much time with people with long-term hepatitis B infections, people with multiple sex partners, men who have sex with men, sex workers, injection drug abusers, and people traveling to high-risk areas. Vaccines may not fully protect everyone who receives them.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

1 NDC package is crosswalked to 90759. Package detail is available to logged-in subscribers.

Login to view 1 NDC package View pricing, complete NDC-to-HCPCS alignments, and package details.
Login →

PREHEVBRIO Vaccine Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
90471 Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections), one vaccine (single or combination vaccine/toxoid)
90472 Immunization administration (each additional vaccine or toxoid), when performed in conjunction with primary procedure.

PREHEVBRIO Medically Unlikely Edits (MUE)

The most billing units of 90759 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mcg.

Practitioner Office & Hospital Outpatient
1 unit / day
= 10 mcg per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

mcg Enter a dose to see how many billing units it is and whether it is under the limit.

PREHEVBRIO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Hepatitis B virus infection

Login for BuyandBill.com Analytics

Unlock deeper insights with BuyandBill’s Comparative Report!

  • Compare ASP, WAC, and AWP across drugs.
  • Visualize Drug Price Movement Over Time
  • Tailor reports to drug class, manufacturer, or HCPCS Code.
  • Compare Biosimilar and 505(b)(2) products.

Frequently Asked Questions

Is there an available Prehevbrio billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for PREHEVBRIO.
Are there any available Prehevbrio patient assistance programs?
Our team has not identified a manufacturer-published source of patient assistance information for PREHEVBRIO.
Where can I find Prehevbrio prescribing information?
PREHEVBRIO prescribing information can be found at the link below: Visit Here →
Where can I find Prehevbrio side effect information?
Information regarding PREHEVBRIO's side effects can be found at MedlinePlus Visit Here →
Does billing PREHEVBRIO require JZ/JW wastage modifiers?
CMS does not include PREHEVBRIO (90759) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing 90759. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.