HEPLISAV-B CPT Vaccine Code: 90739

Vaccine & Product Overview

HCPCS Descriptor Hepatitis B vaccine (HepB), CpG-adjuvanted, adult dosage, 2 dose or 4 dose schedule, for intramuscular use

Manufacturer Dynavax

Route of Administration Intramuscular

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About HEPLISAV-B

Heplisav-b is a medication aligned to the HCPCS CPT Drug Code: 90739 for billing, pricing, and reimbursement purposes in the United States. Classified under Vaccine, it is administered via the intramuscular route and manufactured by Dynavax.

According to CMS Drug Use Information: This vaccine is used to help prevent hepatitis B. Hepatitis B infection can cause serious problems including liver failure, long-term hepatitis B infection, cirrhosis, and liver cancer. Vaccination is the best way to protect against this infection. This vaccine works by increasing the body's natural defense (immunity) against the virus. The vaccine is recommended for people of all ages, especially those at an increased risk of getting the infection. Those at an increased risk include health care personnel, lab workers who handle blood and patient specimens, police, fire and emergency medical personnel who give first aid treatment, hemophiliacs, dialysis patients, people who live with or spend much time with people with long-term hepatitis B infections, people with multiple sex partners, men who have sex with men, sex workers, injection drug abusers, and people traveling to high-risk areas. Vaccines may not fully protect everyone who receives them.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

2 NDC packages are crosswalked to 90739. Package detail is available to logged-in subscribers.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
•••••-••••-•• Log in to view	HEPLISAV-B
	HEPLISAV-B

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HEPLISAV-B Pricing & Reimbursement

90739 Private Payer Reimbursement

$178.98 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

HEPLISAV-B Vaccine Administration Codes

Medicare bills the administration of HEPLISAV-B with HCPCS code G0010, and allows simplified roster billing when vaccinating multiple patients. The CPT codes below apply to non-Medicare payers.

Code	Description
G0010	Administration of hepatitis B vaccine (Medicare)
90471	Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections), one vaccine (single or combination vaccine/toxoid)
90472	Immunization administration (each additional vaccine or toxoid), when performed in conjunction with primary procedure.

HEPLISAV-B Medically Unlikely Edits (MUE)

The most billing units of 90739 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 dose.

Practitioner Office & Hospital Outpatient

1 unit / day

= 1 dose per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

HEPLISAV-B Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Hepatitis B virus infection

Drug Class

Actively Acquired Immunity [PE]Hepatitis B Vaccines [CS]Inactivated Hepatitis B Virus Vaccine [EPC]VaccinesInactivated [CS]

Frequently Asked Questions

Is there an available Heplisav-B billing and coding guide?

View a Heplisav-B billing and coding guide at the link below: Visit Here →

Are there any available Heplisav-B patient assistance programs?

Our team did not identify a source for Heplisav-B patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Heplisav-B prescribing information?

HEPLISAV-B prescribing information can be found at the link below: Visit Here →

Where can I find Heplisav-B side effect information?

Our team has not yet identified a source of side effects information for HEPLISAV-B. Please check back in a few weeks.

Does billing HEPLISAV-B require JZ/JW wastage modifiers?

CMS does not include HEPLISAV-B (90739) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing 90739. For more information, visit the link below.

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