OPDIVO QVANTIG J Code: J9289

Drug & Product Overview

HCPCS Descriptor Injection, nivolumab, 2 mg and hyaluronidase-nvhy

HCPCS Added Date July 1, 2025

Manufacturer BMS

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About OPDIVO QVANTIG

Opdivo Qvantig is a medication aligned to the HCPCS J Code: J9289 for billing, pricing, and reimbursement purposes in the United States. It is administered via the subcutaneous route and manufactured by BMS.

According to CMS Drug Use Information: This medication is used to treat various types of cancer. It contains 2 ingredients: nivolumab and hyaluronidase. Nivolumab belongs to a class of drugs known as monoclonal antibodies. It works by helping your immune system fight the cancer. Hyaluronidase is used to help the body absorb nivolumab, which helps it work better.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00003-3120-01	Opdivo Qvantig	E.R. Squibb & Sons, L.L.C.	150	300 MG / 2.5 ML
00003-6120-01	Opdivo Qvantig	E.R. Squibb & Sons, L.L.C.	300	600 MG / 5 ML

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OPDIVO QVANTIG Pricing & Reimbursement

J9289 Private Payer Reimbursement

$28.39 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

OPDIVO QVANTIG Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 14.98%

Avg. Days to File 7.6days

Avg. Days to Pay 22.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9289 claims analytics on FocalPoint →

OPDIVO QVANTIG CPT Administration Codes

CPT Code	Description
96401	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic
96409	Chemotherapy administration; intravenous, push technique, single or initial substance/drug

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

OPDIVO QVANTIG Medically Unlikely Edits (MUE)

The most billing units of J9289 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 2 mg.

Practitioner Office & Hospital Outpatient

600 units / day

= 1,200 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

OPDIVO QVANTIG Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Adjuvant treatment of melanoma Advanced renal cell carcinoma Esophageal or gastroesophageal junction cancer Esophageal squamous cell carcinoma Gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma Hepatocellular carcinoma MSI-H or dMMR colorectal cancer MSI-H or dMMR metastatic colorectal cancer Metastatic non-small cell lung cancer Resectable non-small cell lung cancer Squamous cell carcinoma of the head and neck Unresectable or metastatic melanoma Urothelial carcinoma

Drug Class

Endoglycosidase [EPC]Glycoside Hydrolases [CS]Programmed Death Receptor-1 Blocking Antibody [EPC]Programmed Death Receptor-1-directed Antibody Interactions [MoA]

Frequently Asked Questions

Is there an available OPDIVO QVANTIG billing and coding guide?

Billing and coding information for OPDIVO QVANTIG can be found through Bristol-Myers Squibb Company. Visit Here →

Are there any available OPDIVO QVANTIG patient assistance programs?

OPDIVO QVANTIG patient assistance information can be found through Bristol-Myers Squibb Company. Visit Here →

Where can I find OPDIVO QVANTIG prescribing information?

OPDIVO QVANTIG prescribing information can be found at the link below. Visit Here →

Where can I find OPDIVO QVANTIG side effect information?

Side effect information for OPDIVO QVANTIG can be found through MedlinePlus. Visit Here →

Does billing OPDIVO QVANTIG require JZ/JW wastage modifiers?

CMS does not include OPDIVO QVANTIG (J9289) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9289. For more information, visit the link below.

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