YERVOY J Code: J9228

Drug & Product Overview

HCPCS Descriptor Injection, ipilimumab, 1 mg

HCPCS Added Date January 1, 2012

Manufacturer BMS

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection

About YERVOY

Yervoy is a medication aligned to the HCPCS J Code: J9228 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intravenous route and manufactured by BMS.

According to CMS Drug Use Information: Ipilimumab is used to treat various cancers. Ipilimumab belongs to a class of drugs known as monoclonal antibodies. It works by slowing or stopping the growth of cancer cells. However, it can have serious side effects in other parts of your body (see also Side Effects section).

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00003-2327-11	Yervoy	E.R. Squibb & Sons, L.L.C.	50	50 MG / 10 ML
00003-2328-22	Yervoy	E.R. Squibb & Sons, L.L.C.	200	200 MG / 40 ML

Login for the full NDC crosswalk View pricing, complete NDC-to-HCPCS alignments, and package details.

Login →

YERVOY Pricing & Reimbursement

J9228 Private Payer Reimbursement

$192.84 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

YERVOY Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 12.88%

Avg. Days to File 9.4days

Avg. Days to Pay 29.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9228 claims analytics on FocalPoint →

YERVOY CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Yervoy (J9228) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

YERVOY Medically Unlikely Edits (MUE)

The most billing units of J9228 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

1,100 units / day

= 1,100 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

YERVOY Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Advanced Renal Cell Carcinoma Esophageal Squamous Cell Carcinoma Hepatocellular Carcinoma Malignant Pleural Mesothelioma Melanoma Metastatic Non-Small Cell Lung Cancer Metastatic or Recurrent Non-Small Cell Lung Cancer Microsatellite Instability-High or Mismatch Repair Deficient Metastatic Colorectal Cancer Unresectable or Metastatic Melanoma

Drug Class

CTLA-4-directed Antibody Interactions [MoA]CTLA-4-directed Blocking Antibody [EPC]Increased T Lymphocyte Activation [PE]

Frequently Asked Questions

Is there an available Yervoy billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for YERVOY.

Are there any available Yervoy patient assistance programs?

YERVOY patient assistance information can be found through BMS. Visit Here →

Where can I find Yervoy prescribing information?

YERVOY prescribing information can be found at the link below: Visit Here →

Where can I find Yervoy side effect information?

Information regarding YERVOY's side effects can be found at MedlinePlus Visit Here →

Does billing YERVOY require JZ/JW wastage modifiers?

CMS has identified YERVOY(J9228) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.