KEYTRUDA J Code: J9271

Drug & Product Overview

HCPCS Descriptor Injection, pembrolizumab, 1 mg

HCPCS Added Date January 1, 2016

Manufacturer Merck Sharp & Dohme Corp

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About KEYTRUDA

Keytruda is a medication aligned to the HCPCS J Code: J9271 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intravenous route and manufactured by Merck Sharp & Dohme Corp.

According to CMS Drug Use Information: Pembrolizumab is used to treat cancer. It works by changing how your immune system works, making it attack cancer cells. Pembrolizumab belongs to a class of drugs known as monoclonal antibodies.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00006-3026-02	Keytruda	Merck Sharp & Dohme LLC	100	100 MG / 4 ML
00006-3026-04	Keytruda	Merck Sharp & Dohme LLC	200	100 MG / 4 ML

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KEYTRUDA Pricing & Reimbursement

J9271 Private Payer Reimbursement

$61.95 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

KEYTRUDA Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 10.68%

Avg. Days to File 7.9days

Avg. Days to Pay 25.1days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9271 claims analytics on FocalPoint →

KEYTRUDA CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Keytruda (J9271) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

KEYTRUDA Medically Unlikely Edits (MUE)

The most billing units of J9271 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

400 units / day

= 400 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

KEYTRUDA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Biliary Tract Cancer Cervical Cancer Classical Hodgkin Lymphoma Cutaneous Squamous Cell Carcinoma Endometrial Carcinoma Esophageal Cancer Gastric Cancer Head and Neck Squamous Cell Cancer Hepatocellular Carcinoma MSI-H or dMMR Cancer MSI-H or dMMR Colorectal Cancer Malignant Pleural Mesothelioma Melanoma Merkel Cell Carcinoma Muscle Invasive Bladder Cancer Non-Muscle Invasive Bladder Cancer Non-Small Cell Lung Cancer Ovarian Cancer Primary Mediastinal Large B-Cell Lymphoma Renal Cell Carcinoma Triple-Negative Breast Cancer Tumor Mutational Burden-High Cancer Urothelial Cancer Urothelial Carcinoma

Show all 24 conditions Show fewer

Drug Class

Programmed Death Receptor-1 Blocking Antibody [EPC]Programmed Death Receptor-1-directed Antibody Interactions [MoA]

Frequently Asked Questions

Is there an available Keytruda billing and coding guide?

Billing and coding information for KEYTRUDA can be found through Merck. Visit Here →

Are there any available Keytruda patient assistance programs?

KEYTRUDA patient assistance information can be found through Merck Sharp & Dohme Corp. Visit Here →

Where can I find Keytruda prescribing information?

KEYTRUDA prescribing information can be found at the link below: Visit Here →

Where can I find Keytruda side effect information?

Information regarding KEYTRUDA's side effects can be found at MedlinePlus Visit Here →

Does billing KEYTRUDA require JZ/JW wastage modifiers?

CMS has identified KEYTRUDA(J9271) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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