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Updated July 1st, 2026

MOXIFLOXACIN HCL J Code: J2281

Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg

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Q4 2026 Medicare Payment Limit for J2281, effective October 1, 2026: $6.641 per HCPCS billing unit, unchanged from Q3 2026. From CMS's final file.

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Medicare Payment Limit ?
$6.641
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
2
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Drug & Product Overview

HCPCS Descriptor Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg
HCPCS Added Date January 1, 2023
Manufacturer Fresenius Kabi
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About MOXIFLOXACIN HCL

Moxifloxacin HCL is a medication aligned to the HCPCS J Code: J2281 for billing, pricing, and reimbursement purposes in the United States. It is an Antibiotic drug administered via the intravenous route and manufactured by Fresenius Kabi.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. Showing 1 of 2 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
63323-0850-74 Moxifloxacin HCl FreseniUS Kabi USA, LLC 48 400 MG / 250 ML
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MOXIFLOXACIN HCL Pricing & Reimbursement

J2281 Private Payer Reimbursement
$6.73 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Moxifloxacin 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J2280 Mylan Pharmaceuticals Moxifloxacin Injection, moxifloxacin, 100 mg
J2281 Fresenius Kabi Moxifloxacin Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg

MOXIFLOXACIN HCL CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
Not on the CMS JW / JZ list

CMS does not include Moxifloxacin HCL (J2281) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2281. Wastage billing guide →

MOXIFLOXACIN HCL Medically Unlikely Edits (MUE)

The most billing units of J2281 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 100 mg.

Practitioner Office & Hospital Outpatient
4 units / day
= 400 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

MOXIFLOXACIN HCL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Bacterial Exacerbation of Chronic Bronchitis Acute Bacterial Sinusitis Community Acquired Pneumonia Complicated Intra-Abdominal Infections Complicated Skin and Skin Structure Infections Uncomplicated Skin and Skin Structure Infections
Drug Class
Fluoroquinolone Antibacterial [EPC]Fluoroquinolones [CS]

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Frequently Asked Questions

Is there an available Moxifloxacin Hcl billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for MOXIFLOXACIN HCL.
Are there any available Moxifloxacin Hcl patient assistance programs?
MOXIFLOXACIN HCL patient assistance information can be found through Fresenius Kabi. Visit Here →
Where can I find Moxifloxacin Hcl prescribing information?
MOXIFLOXACIN HCL prescribing information can be found at the link below: Visit Here →
Where can I find Moxifloxacin Hcl side effect information?
Information regarding MOXIFLOXACIN HCL's side effects can be found at MedlinePlus Visit Here →
Does billing MOXIFLOXACIN HCL require JZ/JW wastage modifiers?
CMS does not include MOXIFLOXACIN HCL (J2281) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2281. For more information, visit the link below.

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