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Updated July 1st, 2026

AVELOX I.V. J Code: J2280

Injection, moxifloxacin, 100 mg

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Q4 2026 Medicare Payment Limit for J2280, effective October 1, 2026: $8.744 per HCPCS billing unit, unchanged from Q3 2026. From CMS's final file.

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Medicare Payment Limit ?
$8.744
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
1
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Drug & Product Overview

HCPCS Descriptor Injection, moxifloxacin, 100 mg
HCPCS Added Date January 1, 2004
Manufacturer Mylan Pharmaceuticals
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About AVELOX I.V.

Avelox I.V. is a medication aligned to the HCPCS J Code: J2280 for billing, pricing, and reimbursement purposes in the United States. This Antibiotic medication is administered via the intravenous route and manufactured by Mylan Pharmaceuticals.

According to CMS Drug Use Information: This medication is used to treat a variety of bacterial infections. Moxifloxacin belongs to a class of drugs called quinolone antibiotics. It works by stopping the growth of bacteria. Moxifloxacin injection is used when you cannot take the medication by mouth.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
67457-0323-25 Moxifloxacin Hydrochloride Mylan Institutional LLC 48 400 MG / 250 ML
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AVELOX I.V. Pricing & Reimbursement

J2280 Private Payer Reimbursement
$9.17 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Moxifloxacin 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J2280 Mylan Pharmaceuticals Moxifloxacin Injection, moxifloxacin, 100 mg
J2281 Fresenius Kabi Moxifloxacin Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg

AVELOX I.V. CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
Not on the CMS JW / JZ list

CMS does not include Avelox I.V. (J2280) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2280. Wastage billing guide →

AVELOX I.V. Medically Unlikely Edits (MUE)

The most billing units of J2280 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 100 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
4 units / day
= 400 mg per day
Hospital Outpatient
8 units / day
= 800 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

AVELOX I.V. Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Bacterial Exacerbation of Chronic Bronchitis Acute Bacterial Sinusitis Community Acquired Pneumonia Complicated Intra-Abdominal Infections Complicated Skin and Skin Structure Infections Plague Uncomplicated Skin and Skin Structure Infections
Drug Class
Fluoroquinolone Antibacterial [EPC]Fluoroquinolones [CS]

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Frequently Asked Questions

Is there an available Avelox I.V. billing and coding guide?
We have not yet identified a manufacturer source of Avelox I.V. billing and coding information.
Are there any available Avelox I.V. patient assistance programs?
Our team did not identify a source for Avelox I.V. patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Avelox I.V. prescribing information?
AVELOX I.V. prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →
Where can I find Avelox I.V. side effect information?
Our team has not yet identified a source of side effects information for AVELOX I.V.. Please check back in a few weeks.
Does billing AVELOX I.V. require JZ/JW wastage modifiers?
CMS does not include AVELOX I.V. (J2280) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2280. For more information, visit the link below.

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