Leucovorin Calcium J Code: J0643

Drug & Product Overview

HCPCS Descriptor Injection, leucovorin calcium, not otherwise specified, 1 mg

HCPCS Added Date October 1, 2026

Manufacturer Multiple Manufacturers

Route of Administration Intramuscular, Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection | Injection, Powder, Lyophilized, For Solution | Injection, Powder, Lyophilized, For Suspension

About Leucovorin Calcium

Leucovorin Calcium is a medication aligned to the HCPCS J Code: J0643 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intramuscular or intravenous routes and manufactured by multiple companies.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 35 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00143-9368-01	Leucovorin Calcium	Hikma Pharmaceuticals USA Inc.	200	200 MG / 20 ML
25021-0813-10	Leucovorin Calcium	Sagent Pharmaceuticals	500	50 MG / 5 ML
63323-0631-10	Leucovorin calcium	Fresenius Kabi USA, LLC	100	100 MG / 10 ML
67457-0528-10	Leucovorin Calcium	Mylan Institutional LLC	100	100 MG / 10 ML
68001-0416-36	Leucovorin Calcium	BluePoint Laboratories	100	100 MG / 10 ML
•••••-••••-•• Log in to view	Leucovorin Calcium
	Leucovorin Calcium
	Leucovorin Calcium

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Leucovorin Calcium Pricing & Reimbursement

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Leucovorin Calcium CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96372 Login for More	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

Leucovorin Calcium Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Advanced Colorectal Cancer Advanced colorectal cancer Impaired Methotrexate Elimination or Inadvertent Overdosage Impaired Methotrexate Elimination or Inadvertent Overdosage of Folic Acid Antagonists Impaired methotrexate elimination or inadvertent overdosage Impaired methotrexate elimination or inadvertent overdosage of folic acid antagonists Leucovorin Rescue After High-Dose Methotrexate Therapy in Osteosarcoma Megaloblastic Anemia Due to Folic Acid Deficiency Megaloblastic Anemia due to Folic Acid Deficiency Megaloblastic anemia due to folic acid deficiency Osteosarcoma Osteosarcoma (leucovorin rescue after high-dose methotrexate therapy) Osteosarcoma (leucovorin rescue after high-dose methotrexate) Osteosarcoma (rescue after high-dose methotrexate therapy) Osteosarcoma (rescue after high-dose methotrexate)

Drug Class

Folate Analog [EPC]Folic Acid [CS]

Frequently Asked Questions

Is there an available Leucovorin Calcium billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for Leucovorin Calcium.

Are there any available Leucovorin Calcium patient assistance programs?

Our team has not identified a manufacturer-published source of patient assistance information for Leucovorin Calcium.

Where can I find Leucovorin Calcium prescribing information?

Leucovorin Calcium prescribing information can be found at the link below. Please reach out to us if you believe this information to be inaccurate or out of date. Visit Here →

Where can I find Leucovorin Calcium side effect information?

Our team has not yet identified a source of side effects information for Leucovorin Calcium. Please check back in a few weeks.

Does billing Leucovorin Calcium require JZ/JW wastage modifiers?

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers.

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