LEUCOVORIN CALCIUM J Code: J0640

Drug & Product Overview

HCPCS Descriptor Injection, leucovorin calcium, per 50 mg

HCPCS Added Date January 1, 1982

Manufacturer Multiple Manufacturers

Route of Administration Intramuscular, Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection | Injection, Powder, Lyophilized, For Solution | Injection, Powder, Lyophilized, For Suspension

About LEUCOVORIN CALCIUM

Leucovorin Calcium is a medication aligned to the HCPCS J Code: J0640 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intramuscular or intravenous routes and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to treat or prevent serious blood cell disorders (such as thrombocytopenia, neutropenia, anemia) caused by certain drugs (folic acid antagonists such as methotrexate, trimethoprim, pyrimethamine). It may also be used with a certain cancer drug (5-fluorouracil) to treat patients with colon cancer. Leucovorin may also be used to treat a certain type of anemia (due to folic acid deficiency) when folic acid cannot be taken by mouth.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 39 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00143-9368-01	Leucovorin Calcium	Hikma Pharmaceuticals USA Inc.	4	200 MG / 20 ML
25021-0813-10	Leucovorin Calcium	Sagent Pharmaceuticals	10	50 MG / 5 ML
63323-0631-10	Leucovorin calcium	Fresenius Kabi USA, LLC	2	100 MG / 10 ML
67457-0528-10	Leucovorin Calcium	Mylan Institutional LLC	2	100 MG / 10 ML
68001-0416-36	Leucovorin Calcium	BluePoint Laboratories	2	100 MG / 10 ML
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LEUCOVORIN CALCIUM Pricing & Reimbursement

J0640 Private Payer Reimbursement

$3.74 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

LEUCOVORIN CALCIUM Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 8.79%

Avg. Days to File 11.0days

Avg. Days to Pay 25.7days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J0640 claims analytics on FocalPoint →

LEUCOVORIN CALCIUM CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96372 Login for More	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More

Not on the CMS JW / JZ list

CMS does not include Leucovorin Calcium (J0640) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0640. Wastage billing guide →

LEUCOVORIN CALCIUM Medically Unlikely Edits (MUE)

The most billing units of J0640 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mg.

Practitioner Office & Hospital Outpatient

24 units / day

= 1,200 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

LEUCOVORIN CALCIUM Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Advanced Colorectal Cancer Advanced colorectal cancer Impaired Methotrexate Elimination or Inadvertent Overdosage Impaired Methotrexate Elimination or Inadvertent Overdosage of Folic Acid Antagonists Impaired methotrexate elimination or inadvertent overdosage Impaired methotrexate elimination or inadvertent overdosage of folic acid antagonists Leucovorin Rescue After High-Dose Methotrexate Therapy in Osteosarcoma Megaloblastic Anemia Due to Folic Acid Deficiency Megaloblastic Anemia due to Folic Acid Deficiency Megaloblastic anemia due to folic acid deficiency Osteosarcoma Osteosarcoma (leucovorin rescue after high-dose methotrexate therapy) Osteosarcoma (leucovorin rescue after high-dose methotrexate) Osteosarcoma (rescue after high-dose methotrexate therapy) Osteosarcoma (rescue after high-dose methotrexate)

Drug Class

Folate Analog [EPC]Folic Acid [CS]

Frequently Asked Questions

Is there an available Leucovorin Calcium billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for LEUCOVORIN CALCIUM.

Are there any available Leucovorin Calcium patient assistance programs?

Our team has not identified a manufacturer-published source of patient assistance information for LEUCOVORIN CALCIUM.

Where can I find Leucovorin Calcium prescribing information?

Our team is still working to identify a prescribing information source for LEUCOVORIN CALCIUM

Where can I find Leucovorin Calcium side effect information?

Our team has not yet identified a source of side effects information for LEUCOVORIN CALCIUM. Please check back in a few weeks.

Does billing LEUCOVORIN CALCIUM require JZ/JW wastage modifiers?

CMS does not include LEUCOVORIN CALCIUM (J0640) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0640. For more information, visit the link below.

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