Vykoura C Code: C9310

Drug & Product Overview

HCPCS Descriptor Injection, leucovorin calcium (avyxa), 1 mg

HCPCS Added Date July 1, 2026

Manufacturer Avyxa Pharma

Route of Administration Intramuscular, Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection

About Vykoura

Vykoura is a medication aligned to the HCPCS C Code: C9310 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intramuscular or intravenous routes and manufactured by Avyxa Pharma.

Manufacturers, reach out to us to add more information.

NDC Code Information

3 NDC packages are crosswalked to C9310. Package detail is available to logged-in subscribers.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
•••••-••••-•• Log in to view	Vykoura
	Vykoura
	Vykoura

Login to view 3 NDC packages View pricing, complete NDC-to-HCPCS alignments, and package details.

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Leucovorin Calcium 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
C9310	Avyxa Pharma	Leucovorin Calcium	Injection, leucovorin calcium (avyxa), 1 mg
J0644	Avyxa Pharma	Leucovorin Calcium	Injection, leucovorin calcium (avyxa), 1 mg

Vykoura Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 80.68%

Avg. Days to File 4.0days

Avg. Days to Pay 0.0days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore C9310 claims analytics on FocalPoint →

Vykoura CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96372 Login for More	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

Vykoura Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Impaired methotrexate elimination or overdose of folic acid antagonists or dihydrofolate reductase (DHFR) inhibitors Megaloblastic anemia due to folic acid deficiency Metastatic colorectal cancer Rescue after high-dose methotrexate therapy

Drug Class

Folate Analog [EPC]Folic Acid [CS]

Frequently Asked Questions

Is there an available Vykoura billing and coding guide?

Billing and coding information for VYKOURA can be found through Avyxa Pharma. Visit Here →

Are there any available Vykoura patient assistance programs?

VYKOURA patient assistance information can be found through AVYXA PHARMA. Visit Here →

Where can I find Vykoura prescribing information?

VYKOURA prescribing information can be found at the link below: Visit Here →

Where can I find Vykoura side effect information?

No VYKOURA side effect information link was found.

Does billing VYKOURA require JZ/JW wastage modifiers?

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers.

About BuyandBill.com:

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