METHOTREXATE J Code: J9260
Injection, methotrexate sodium, 50 mg
Q4 2026 Medicare Payment Limit for J9260, effective October 1, 2026: $2.909 per HCPCS billing unit, down 1.1% from $2.941. From CMS's final file.
Drug & Product Overview
About METHOTREXATE
Methotrexate is a medication aligned to the HCPCS J Code: J9260 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology, it is administered via the intra-arterial, intramuscular, intrathecal, intravenous, or subcutaneous routes and manufactured by multiple companies.
According to CMS Drug Use Information: Methotrexate is used to treat certain types of cancer, severe psoriasis, or rheumatoid arthritis. It may also be used to treat a certain type of arthritis in children (polyarticular juvenile idiopathic arthritis - pJIA). Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and blocking the immune system from attacking healthy tissue. Early treatment of rheumatoid arthritis with methotrexate helps to reduce further joint damage and to preserve joint function.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 19 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00143-9367-01 | Methotrexate | Hikma Pharmaceuticals USA Inc. | 20 | Methotrexate Intra-Art erial Injection … Login for More |
| 00703-3671-01 | Methotrexate | Teva Parenteral Medicines, Inc. | 1 | 50 MG / 2 ML |
| 16729-0277-30 | Methotrexate | Accord Healthcare, Inc. | 1 | 50 MG / 2 ML |
| 61703-0124-40 | Methotrexate | Hospira, Inc. | 20 | 1000 MG / 40 ML |
| 63323-0122-50 | Methotrexate | Fresenius Kabi USA, LLC | 20 | Methotrexate Intra-Art erial Injection … Login for More |
| •••••-••••-•• Log in to view | METHOTREXATE | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | METHOTREXATE | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | METHOTREXATE | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
METHOTREXATE Pricing & Reimbursement
National median reimbursement across major commercial payers.
Create an account on PayerPrice for more information →
Historical Graphing and Billing Calculator
Log in to calculate billing and reimbursement with live ASP, WAC & AWP pricing.
Login to use the calculator →METHOTREXATE CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
| 96401 | Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic |
| 96409 Login for More | Chemotherapy administration; intravenous, push technique, single or initial substance/drug Login for More |
| 96413 Login for More | Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug Login for More |
| 96415 Login for More | Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure) Login for More |
CMS does not include Methotrexate (J9260) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9260. Wastage billing guide →
METHOTREXATE Medically Unlikely Edits (MUE)
The most billing units of J9260 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
METHOTREXATE Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
No conditions match your search.
Login for BuyandBill.com Analytics
Unlock deeper insights with BuyandBill’s Comparative Report!
- Compare ASP, WAC, and AWP across drugs.
- Visualize Drug Price Movement Over Time
- Tailor reports to drug class, manufacturer, or HCPCS Code.
- Compare Biosimilar and 505(b)(2) products.
Frequently Asked Questions
Is there an available Methotrexate billing and coding guide?
Are there any available Methotrexate patient assistance programs?
Where can I find Methotrexate prescribing information?
Where can I find Methotrexate side effect information?
Does billing METHOTREXATE require JZ/JW wastage modifiers?
About BuyandBill.com:
The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.
Related Drug Codes
Explore billing, coding, and pricing for drugs related to METHOTREXATE.
