Home Drug Codes J Codes J9250 · METHOTREXATE
Updated July 1st, 2026

METHOTREXATE J Code: J9250

Methotrexate sodium, 5 mg

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Medicare Payment Limit ?
Not published
CMS publishes none for Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
No current ASP
Not available for Q3 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
19
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Drug & Product Overview

HCPCS Descriptor Methotrexate sodium, 5 mg
HCPCS Added Date January 1, 1994
Manufacturer Multiple Manufacturers
Route of Administration Intra-Arterial, Intramuscular, Intrathecal, Intravenous, Subcutaneous
Generic Status HCPCS Discontinued
Dosage Type Single-Dose, Multi-Dose
Dosage Form Injection | Injection, Powder, Lyophilized, For Solution | Injection, Solution | Not Available | Solution

About METHOTREXATE

Methotrexate is a medication aligned to the HCPCS J Code: J9250 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intra-arterial, intramuscular, intrathecal, intravenous, or subcutaneous routes and manufactured by multiple companies.

Manufacturers, reach out to us to add more information.

NDC Code Information

19 NDC packages are crosswalked to J9250. Package detail is available to logged-in subscribers.

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METHOTREXATE CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
96401 Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic
96409 Login for More Chemotherapy administration; intravenous, push technique, single or initial substance/drug Login for More
96413 Login for More Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug Login for More
96415 Login for More Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure) Login for More
Not on the CMS JW / JZ list

CMS does not include Methotrexate (J9250) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9250. Wastage billing guide →

METHOTREXATE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Lymphoblastic Leukemia Breast Cancer Burkitt's Tumor (Non-Hodgkin's Lymphoma) Choriocarcinoma and Similar Trophoblastic Diseases Epidermoid Cancers of the Head and Neck Gestational Trophoblastic Neoplasia Lung Cancer Lymphosarcoma (Non-Hodgkin's Lymphoma) Meningeal Leukemia Mycosis Fungoides (Cutaneous T Cell Lymphoma) Non-Hodgkin Lymphoma Non-Hodgkin's Lymphomas (advanced stage) Osteosarcoma Polyarticular Juvenile Idiopathic Arthritis Polyarticular-Course Juvenile Rheumatoid Arthritis Psoriasis Rheumatoid Arthritis Squamous Cell Carcinoma of the Head and Neck
Drug Class
Folate Analog Metabolic Inhibitor [EPC]Folic Acid Metabolism Inhibitors [MoA]

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Frequently Asked Questions

Is there an available Methotrexate billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for METHOTREXATE.
Are there any available Methotrexate patient assistance programs?
Our team has not identified a manufacturer-published source of patient assistance information for METHOTREXATE.
Where can I find Methotrexate prescribing information?
METHOTREXATE prescribing information can be found at the link below: Visit Here →
Where can I find Methotrexate side effect information?
Information regarding METHOTREXATE's side effects can be found at MedlinePlus Visit Here →
Does billing METHOTREXATE require JZ/JW wastage modifiers?
CMS does not include METHOTREXATE (J9250) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9250. For more information, visit the link below.

About BuyandBill.com:

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