HYDROXOCOBALAMIN J Code: J3425

Drug & Product Overview

HCPCS Descriptor Injection, hydroxocobalamin, intramuscular, 10 mcg

HCPCS Added Date January 1, 2024

Manufacturer Teva

Route of Administration Intramuscular

Generic Status Single-Source; Branded

Dosage Type Multi-Dose

Dosage Form Injection, Solution

About HYDROXOCOBALAMIN

Hydroxocobalamin is a medication aligned to the HCPCS J Code: J3425 for billing, pricing, and reimbursement purposes in the United States. Classified under Hematology, it is administered via the intramuscular route and manufactured by Teva.

According to CMS Drug Use Information: Hydroxocobalamin is a man-made injectable form of vitamin B12 used to treat low levels (deficiency) of this vitamin. Vitamin B12 helps your body use fat and carbohydrates for energy and make new protein. It is also important for normal blood, cells, and nerves. Most people get enough vitamin B12 in their diet, but a deficiency may occur in certain health conditions (such as poor nutrition, stomach/intestinal problems, infection, cancer). Serious vitamin B12 deficiency may result in anemia, stomach problems, and nerve damage.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00591-2888-30	Hydroxocobalamin	Actavis Pharma, Inc.	3000	30000 MCG / 30 ML

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HYDROXOCOBALAMIN Pricing & Reimbursement

J3425 Private Payer Reimbursement

$0.02 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Hydroxocobalamin 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J3424	Generic Code (Multiple Manufacturers)	Hydroxocobalamin	Injection, hydroxocobalamin, intravenous, 25 mg
J3425	Teva	Hydroxocobalamin	Injection, hydroxocobalamin, intramuscular, 10 mcg

HYDROXOCOBALAMIN CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

HYDROXOCOBALAMIN Medically Unlikely Edits (MUE)

The most billing units of J3425 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mcg.

Practitioner Office & Hospital Outpatient

20 units / day

= 200 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

HYDROXOCOBALAMIN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Schilling Test Vitamin B12 Deficiency

Drug Class

Antidote [EPC]

Frequently Asked Questions

Is there an available Hydroxocobalamin billing and coding guide?

We have not yet identified a manufacturer source of Hydroxocobalamin billing and coding information.

Are there any available Hydroxocobalamin patient assistance programs?

Our team did not identify a source for Hydroxocobalamin patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Hydroxocobalamin prescribing information?

HYDROXOCOBALAMIN prescribing information can be found at the link below: Visit Here →

Where can I find Hydroxocobalamin side effect information?

Information regarding HYDROXOCOBALAMIN's side effects can be found at MedlinePlus Visit Here →

Does billing HYDROXOCOBALAMIN require JZ/JW wastage modifiers?

CMS does not include HYDROXOCOBALAMIN (J3425) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J3425. For more information, visit the link below.

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