Home › Drug Codes › J Codes › J9351 · HYCAMTIN
Updated July 1st, 2026

HYCAMTIN J Code: J9351

Injection, topotecan, 0.1 mg

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Q4 2026 Medicare Payment Limit for J9351, effective October 1, 2026: $2.067 per HCPCS billing unit, down 25.1% from $2.759. From CMS's final file.

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Medicare Payment Limit ?
$2.759
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
9
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Drug & Product Overview

HCPCS Descriptor Injection, topotecan, 0.1 mg
HCPCS Added Date January 1, 2011
Manufacturer Multiple Manufacturers
Route of Administration Intravenous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose, Multi-Dose
Dosage Form Injection | Injection, Powder, Lyophilized, For Solution | Injection, Solution, Concentrate | Not Available

About HYCAMTIN

Hycamtin is a medication aligned to the HCPCS J Code: J9351 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to treat ovarian, lung, or cervical cancer. It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 9 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00409-0302-01 Topotecan Hospira, Inc. 40 4 MG / 4 ML
16729-0151-31 topotecan hydrochloride Accord Healthcare, Inc. 40 4 MG / 4 ML
16729-0243-31 Topotecan Accord Healthcare Inc. 40 4 MG / 4 ML
45963-0615-56 Topotecan hydrochloride Actavis Pharma, Inc. 40 4 MG / 4 ML
63323-0762-10 Topotecan Hydrochloride Fresenius Kabi USA, LLC 40 4 MG / 4 ML
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HYCAMTIN Pricing & Reimbursement

J9351 Private Payer Reimbursement
$3.37 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

HYCAMTIN Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 9.47%
Avg. Days to File 8.2days
Avg. Days to Pay 22.6days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9351 claims analytics on FocalPoint →
OnPoint Oncology

HYCAMTIN CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96413 Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415 Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)
Not on the CMS JW / JZ list

CMS does not include Hycamtin (J9351) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9351. Wastage billing guide →

HYCAMTIN Medically Unlikely Edits (MUE)

The most billing units of J9351 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg.

Practitioner Office & Hospital Outpatient
120 units / day
= 12 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

HYCAMTIN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Cervical Cancer Metastatic Ovarian Cancer Ovarian Cancer Small Cell Lung Cancer
Drug Class
Topoisomerase Inhibitor [EPC]Topoisomerase Inhibitors [MoA]

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Frequently Asked Questions

Is there an available Hycamtin billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for HYCAMTIN.
Are there any available Hycamtin patient assistance programs?
Our team has not identified a manufacturer-published source of patient assistance information for HYCAMTIN.
Where can I find Hycamtin prescribing information?
HYCAMTIN prescribing information can be found at the link below: Visit Here →
Where can I find Hycamtin side effect information?
Information regarding HYCAMTIN's side effects can be found at MedlinePlus Visit Here →
Does billing HYCAMTIN require JZ/JW wastage modifiers?
CMS does not include HYCAMTIN (J9351) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9351. For more information, visit the link below.

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