Heparin J Code: J1642

Drug & Product Overview

HCPCS Descriptor Injection, heparin sodium, (heparin lock flush), per 10 units

HCPCS Added Date January 1, 1995

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

About Heparin

Heparin is a medication aligned to the HCPCS J Code: J1642 for billing, pricing, and reimbursement purposes in the United States. It is a Hematology drug administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to keep IV catheters open and flowing freely. Heparin helps to keep blood flowing smoothly and from clotting in the catheter by making a certain natural substance in your body (anti-clotting protein) work better. It is known as an anticoagulant. This form of heparin must not be used to treat or prevent blood clots in the body. Some products should not be used for newborns due to an increased risk of side effects. Check with your doctor or pharmacist for more details.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 14 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
64253-0222-21	Heparin (Porcine) Lock Flush	Medefil, Inc.	60	Heparin Na (Pork) Lock Flsh PF Intrave… Login for More
64253-0222-23	Heparin (Porcine) Lock Flush	Medefil, Inc.	180	Heparin Na (Pork) Lock Flsh PF Intrave… Login for More
64253-0222-33	Heparin (Porcine) Lock Flush	Medefil, Inc.	180	Heparin Na (Pork) Lock Flsh PF Intrave… Login for More
64253-0222-35	Heparin (Porcine) Lock Flush	Medefil, Inc.	300	Heparin Na (Pork) Lock Flsh PF Intrave… Login for More
64253-0333-21	Heparin (Porcine) Lock Flush	Medefil, Inc.	600	Heparin Na (Pork) Lock Flsh PF Intrave… Login for More
•••••-••••-•• Log in to view	Heparin
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Heparin Pricing & Reimbursement

J1642 Private Payer Reimbursement

$0.02 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Heparin Sodium 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J1642	Generic Code (Multiple Manufacturers)	Heparin Sodium	Injection, heparin sodium, (heparin lock flush), per 10 units
J1643	Pfizer	Heparin Sodium	Injection, heparin sodium (pfizer), not therapeutically equivalent to j1644, per 1000 units
J1644	Generic Code (Multiple Manufacturers)	Heparin Sodium	Injection, heparin sodium, per 1000 units

Heparin CPT Administration Codes

CPT Code	Description
96375	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); each additional sequential intravenous push of a new substance/drug.

Not on the CMS JW / JZ list

CMS does not include Heparin (J1642) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1642. Wastage billing guide →

Heparin Medically Unlikely Edits (MUE)

The most billing units of J1642 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 units. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

100 units / day

= 1,000 units per day

Hospital Outpatient

150 units / day

= 1,500 units per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

Heparin Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Venous thrombosis Pulmonary embolism Atrial fibrillation with embolization Disseminated intravascular coagulation (acute & chronic consumptive coagulopathies) Peripheral arterial embolism

Frequently Asked Questions

Is there an available Heparin billing and coding guide?

We have not yet identified a manufacturer source of Heparin billing and coding information.

Are there any available Heparin patient assistance programs?

Our team did not identify a source for Heparin patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Heparin prescribing information?

Heparin prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Heparin side effect information?

Our team has not yet identified a source of side effects information for Heparin. Please check back in a few weeks.

Does billing Heparin require JZ/JW wastage modifiers?

CMS does not include Heparin (J1642) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1642. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.