Home › Drug Codes › J Codes › J1566 · GAMMAGARD S-D
Updated July 1st, 2026

GAMMAGARD S-D J Code: J1566

Injection, immune globulin, intravenous, lyophilized (e.g., powder), not otherwise specified, 500 mg

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Q4 2026 Medicare Payment Limit for J1566, effective October 1, 2026: $82.756 per HCPCS billing unit, up 2.2% from $80.961. From CMS's final file.

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Medicare Payment Limit ?
$80.961
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$80.961
/ HCPCS billing unit · APC 2731
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
2
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Drug & Product Overview

HCPCS Descriptor Injection, immune globulin, intravenous, lyophilized (e.g., powder), not otherwise specified, 500 mg
HCPCS Added Date January 1, 2006
Manufacturer Takeda Pharmaceuticals
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Form Kit

About GAMMAGARD S-D

Gammagard S-D is a medication aligned to the HCPCS J Code: J1566 for billing, pricing, and reimbursement purposes in the United States. This Immunoglobulin medication is administered via the intravenous route and manufactured by Takeda Pharmaceuticals.

According to CMS Drug Use Information: This medication is used to strengthen the body's natural defense system (immune system) to lower the risk of infection in persons with a weakened immune system. This medication is made from healthy human blood that has a high level of certain defensive substances (antibodies), which help fight infections. It is also used to increase the blood count (platelets) in persons with a certain blood disorder (idiopathic thrombocytopenia purpura-ITP). Platelets are needed to stop bleeding and form blood clots. Some immune globulin products may also be used to treat certain types of muscle weakness problem (multifocal motor neuropathy, dermatomyositis) or a certain nerve disorder (chronic inflammatory demyelinating polyneuropathy-CIDP). Some products may also be used to prevent certain blood vessel disorders in people with Kawasaki syndrome.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00944-2656-03 Gammagard S/D Takeda Pharmaceuticals America, Inc. 10 Kit
00944-2658-04 Gammagard S/D Takeda Pharmaceuticals America, Inc. 20 Kit
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GAMMAGARD S-D Pricing & Reimbursement

J1566 Private Payer Reimbursement
$81.75 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Immune Globulin 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J1552 GC Biopharma Immune Globulin Injection, immune globulin (alyglo), 500 mg
J1566 Takeda Pharmaceuticals Immune Globulin Injection, immune globulin, intravenous, lyophilized (e.g., powder), not otherwise specified, 500 mg
J1576 Generic Code (Multiple Manufacturers) Immune Globulin Injection, immune globulin (panzyga), intravenous, non-lyophilized (e.g., liquid), 500 mg

GAMMAGARD S-D CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
Not on the CMS JW / JZ list

CMS does not include Gammagard S-D (J1566) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1566. Wastage billing guide →

GAMMAGARD S-D Medically Unlikely Edits (MUE)

The most billing units of J1566 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 500 mg.

Practitioner Office & Hospital Outpatient
300 units / day
= 150,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

GAMMAGARD S-D Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

B-cell Chronic Lymphocytic Leukemia (CLL) Idiopathic Thrombocytopenic Purpura (ITP) Kawasaki Syndrome Measles Exposure (prophylaxis) Primary Immunodeficiency (PI)

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Frequently Asked Questions

Is there an available Gammagard S-D billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for GAMMAGARD S-D.
Are there any available Gammagard S-D patient assistance programs?
GAMMAGARD S-D patient assistance information can be found through Baxalta. Visit Here →
Where can I find Gammagard S-D prescribing information?
GAMMAGARD S-D prescribing information can be found at the link below: Visit Here →
Where can I find Gammagard S-D side effect information?
Our team has not yet identified a source of side effects information for GAMMAGARD S-D. Please check back in a few weeks.
Does billing GAMMAGARD S-D require JZ/JW wastage modifiers?
CMS does not include GAMMAGARD S-D (J1566) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1566. For more information, visit the link below.

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Related Drug Codes

Explore billing, coding, and pricing for drugs related to GAMMAGARD S-D.

J1576PANZYGAInjection, immune globulin (panzyga), intravenous, non-lyophilized (e.g., liquid), 500 mgOctapharmaAdded July 1, 2023J1599PANZYGAInjection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mgOctapharmaAdded January 1, 2011J1559HIZENTRAInjection, immune globulin (hizentra), 100 mgCSL BehringAdded January 1, 2011J1561GAMMAKEDInjection, immune globulin, (gamunex-c/gammaked), non-lyophilized (e.g., liquid), 500 mgGrifolsAdded January 1, 2008J9185FLUDARABINE PHOSPHATEInjection, fludarabine phosphate, 50 mgMultiple ManufacturersAdded January 1, 1994J0850CYTOGAMInjection, cytomegalovirus immune globulin intravenous (human), per vialKamadaAdded January 1, 1982J1459PRIVIGENInjection, immune globulin (privigen), intravenous, non-lyophilized (e.g., liquid), 500 mgCSL BehringAdded January 1, 2009J1460GAMASTANInjection, gamma globulin, intramuscular, 1 ccGrifolsAdded January 1, 1984J1551CutaquigInjection, immune globulin (cutaquig), 100 mgOctapharmaAdded July 1, 2022J1553YimmugoInjection, immune globulin (yimmugo), 100 mgKedrion BiopharmaAdded April 1, 2026