ALDURAZYME J Code: J1931

Drug & Product Overview

HCPCS Descriptor Injection, laronidase, 0.1 mg

HCPCS Added Date January 1, 2005

Manufacturer Genzyme

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution, Concentrate

About ALDURAZYME

Aldurazyme is a medication aligned to the HCPCS J Code: J1931 for billing, pricing, and reimbursement purposes in the United States. Classified under Enzyme Replacement Therapy, it is administered via the intravenous route and manufactured by Genzyme.

According to CMS Drug Use Information: Laronidase is used to treat a certain rare genetic problem (mucopolysaccharidosis-MPS I). It works by replacing a certain natural substance (lysosomal enzyme) that is missing in people with this genetic problem. This medication improves lung function and how far you can walk. Laronidase is not a cure and treatment must be continued for life.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
58468-0070-01	Aldurazyme	Genzyme Corporation	29	2.9 MG / 5 ML

Login for the full NDC crosswalk View pricing, complete NDC-to-HCPCS alignments, and package details.

Login →

ALDURAZYME Pricing & Reimbursement

J1931 Private Payer Reimbursement

$39.71 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

ALDURAZYME CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Aldurazyme (J1931) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ALDURAZYME Medically Unlikely Edits (MUE)

The most billing units of J1931 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg.

Practitioner Office & Hospital Outpatient

609 units / day

= 60.9 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ALDURAZYME Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Mucopolysaccharidosis I (MPS I), Hurler and Hurler-Scheie forms Mucopolysaccharidosis I (MPS I), Scheie form

Drug Class

Hydrolytic Lysosomal Glycosaminoglycan-specific Enzyme [EPC]alpha-Glucosidases [CS]

Frequently Asked Questions

Is there an available Aldurazyme billing and coding guide?

Billing and coding information for ALDURAZYME can be found through Genzyme. Visit Here →

Are there any available Aldurazyme patient assistance programs?

ALDURAZYME patient assistance information can be found through Genzyme. Visit Here →

Where can I find Aldurazyme prescribing information?

ALDURAZYME prescribing information can be found at the link below: Visit Here →

Where can I find Aldurazyme side effect information?

Our team has not yet identified a source of side effects information for ALDURAZYME. Please check back in a few weeks.

Does billing ALDURAZYME require JZ/JW wastage modifiers?

CMS has identified ALDURAZYME(J1931) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.