XOLAIR J Code: J2357
Injection, omalizumab, 5 mg
Q4 2026 Medicare Payment Limit for J2357, effective October 1, 2026: $45.687 per HCPCS billing unit, down 1.9% from $46.588. From CMS's final file.
Drug & Product Overview
About XOLAIR
Xolair is a medication aligned to the HCPCS J Code: J2357 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Eosinophil Asthma, it is administered via the subcutaneous route and manufactured by Genentech.
According to CMS Drug Use Information: Omalizumab is used to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma that is due to year-round allergens. Controlling symptoms of asthma helps you maintain your normal activities and cuts down on time lost from work or school. Omalizumab may also be used to treat certain growths in the nose (chronic rhinosinusitis with nasal polyps) or to treat hives from an unknown cause (chronic spontaneous urticaria-CSU). Omalizumab is also used in people with a certain type of food allergy (IgE-mediated food allergy) while continuing to avoid food allergens. It may help lower the risk of having serious allergic reactions. This medication must be used regularly to be effective. It does not work right away and should not be used as an emergency treatment for serious allergic reactions or to relieve sudden asthma attacks. If an asthma attack occurs, use your quick-relief inhaler (such as albuterol, salbutamol) as prescribed.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 9 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 50242-0040-62 | Xolair | Genentech, Inc. | 30 | 150 MG / 1.2 ML |
| 50242-0214-01 | Xolair | Genentech, Inc. | 15 | 75 MG / 0.5 ML |
| 50242-0214-03 | Xolair PFS | Genentech, Inc. | 15 | 75 MG / 0.5 ML |
| 50242-0215-01 | Xolair | Genentech, Inc. | 30 | 150 MG / 1 ML |
| 50242-0227-01 | Xolair | Genentech, Inc. | 60 | 300 MG / 2 ML |
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XOLAIR Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →Omalizumab Biosimilar Information:
XOLAIR Approval Date: June 20, 2003
| Product Name | HCPCS Code | Active Ingredient | BLA Type |
|---|---|---|---|
| Xolair | J2357 | Omalizumab | 351(a) Originator Product |
| Omlyclo | Q5154 | Omalizumab | 351(k) Interchangeable |
XOLAIR Claims Performance
Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.
Explore J2357 claims analytics on FocalPoint →
XOLAIR CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
CMS has identified Xolair (J2357) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →
XOLAIR Medically Unlikely Edits (MUE)
The most billing units of J2357 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
XOLAIR Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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