Home Drug Codes J Codes J2357 · XOLAIR
Updated July 1st, 2026

XOLAIR J Code: J2357

Injection, omalizumab, 5 mg

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Q4 2026 Medicare Payment Limit for J2357, effective October 1, 2026: $45.687 per HCPCS billing unit, down 1.9% from $46.588. From CMS's final file.

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Medicare Payment Limit ?
$46.588
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$46.588
/ HCPCS billing unit · APC 9300
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
9
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Drug & Product Overview

HCPCS Descriptor Injection, omalizumab, 5 mg
HCPCS Added Date January 1, 2005
Manufacturer Genentech
Route of Administration Subcutaneous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About XOLAIR

Xolair is a medication aligned to the HCPCS J Code: J2357 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Eosinophil Asthma, it is administered via the subcutaneous route and manufactured by Genentech.

According to CMS Drug Use Information: Omalizumab is used to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma that is due to year-round allergens. Controlling symptoms of asthma helps you maintain your normal activities and cuts down on time lost from work or school. Omalizumab may also be used to treat certain growths in the nose (chronic rhinosinusitis with nasal polyps) or to treat hives from an unknown cause (chronic spontaneous urticaria-CSU). Omalizumab is also used in people with a certain type of food allergy (IgE-mediated food allergy) while continuing to avoid food allergens. It may help lower the risk of having serious allergic reactions. This medication must be used regularly to be effective. It does not work right away and should not be used as an emergency treatment for serious allergic reactions or to relieve sudden asthma attacks. If an asthma attack occurs, use your quick-relief inhaler (such as albuterol, salbutamol) as prescribed.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 9 NDCs — log in for the full crosswalk.

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XOLAIR Pricing & Reimbursement

J2357 Private Payer Reimbursement
$45.38 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Omalizumab Biosimilar Information:

XOLAIR Approval Date: June 20, 2003

Product Name HCPCS Code Active Ingredient BLA Type
Xolair J2357 Omalizumab 351(a) Originator Product
Omlyclo Q5154 Omalizumab 351(k) Interchangeable

XOLAIR Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 43.7%
Avg. Days to File 17.7days
Avg. Days to Pay 23.0days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J2357 claims analytics on FocalPoint →
OnPoint Oncology

XOLAIR CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
JW / JZ modifiers apply

CMS has identified Xolair (J2357) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

XOLAIR Medically Unlikely Edits (MUE)

The most billing units of J2357 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5 mg.

Practitioner Office & Hospital Outpatient
120 units / day
= 600 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

XOLAIR Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Asthma Chronic Rhinosinusitis with Nasal Polyps Chronic Spontaneous Urticaria IgE-Mediated Food Allergy
Drug Class
Anti-IgE [EPC]Decreased IgE Activity [PE]IgE-directed Antibody Interactions [MoA]

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Frequently Asked Questions

Is there an available Xolair billing and coding guide?
Billing and coding information for XOLAIR can be found through Genentech. Visit Here →
Are there any available Xolair patient assistance programs?
XOLAIR patient assistance information can be found through Genentech. Visit Here →
Where can I find Xolair prescribing information?
XOLAIR prescribing information can be found at the link below: Visit Here →
Where can I find Xolair side effect information?
Information regarding XOLAIR's side effects can be found at MedlinePlus Visit Here →
Does billing XOLAIR require JZ/JW wastage modifiers?
CMS has identified XOLAIR(J2357) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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