Home Drug Codes J Codes J2182 · NUCALA
Updated July 1st, 2026

NUCALA J Code: J2182

Injection, mepolizumab, 1 mg

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Q4 2026 Medicare Payment Limit for J2182, effective October 1, 2026: $32.181 per HCPCS billing unit, down 0.3% from $32.281. From CMS's final file.

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Medicare Payment Limit ?
$32.281
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$32.281
/ HCPCS billing unit · APC 9473
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
4
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Drug & Product Overview

HCPCS Descriptor Injection, mepolizumab, 1 mg
HCPCS Added Date January 1, 2017
Manufacturer Multiple Manufacturers
Route of Administration Subcutaneous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Injection, Powder, For Solution | Injection, Solution

About NUCALA

Nucala is a medication aligned to the HCPCS J Code: J2182 for billing, pricing, and reimbursement purposes in the United States. It is an Anti-Eosinophil Asthma drug administered via the subcutaneous route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used along with other medications to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma or ongoing lung disease (chronic obstructive pulmonary disease-COPD). Controlling symptoms of breathing problems helps you do your normal activities and decreases time lost from work or school. Mepolizumab is also used to treat certain other immune system disorders (chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome). This medication works by decreasing a certain type of white blood cell (eosinophils). This effect helps reduce swelling (inflammation) of the airways to make breathing easier. It may also help reduce the size of nasal polyps, and lessen symptoms such as runny/stuffy nose, mucus in the throat, loss of smell, facial pain, and tiredness. This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden asthma attacks or breathing problems. If sudden breathing problems occur, use your quick-relief inhaler as prescribed.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 1 of 4 NDCs — log in for the full crosswalk.

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NUCALA Pricing & Reimbursement

J2182 Private Payer Reimbursement
$31.67 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

NUCALA CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96401 Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic
JW / JZ modifiers apply

CMS has identified Nucala (J2182) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

NUCALA Medically Unlikely Edits (MUE)

The most billing units of J2182 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient
300 units / day
= 300 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

NUCALA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Chronic Obstructive Pulmonary Disease Chronic Rhinosinusitis with Nasal Polyps Eosinophilic Granulomatosis with Polyangiitis Hypereosinophilic Syndrome Severe Asthma
Drug Class
Interleukin-5 Antagonist [EPC]Interleukin-5 Antagonists [MoA]

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Frequently Asked Questions

Is there an available Nucala billing and coding guide?
Billing and coding information for NUCALA can be found through GSK. Visit Here →
Are there any available Nucala patient assistance programs?
NUCALA patient assistance information can be found through GSK. Visit Here →
Where can I find Nucala prescribing information?
NUCALA prescribing information can be found at the link below: Visit Here →
Where can I find Nucala side effect information?
Information regarding NUCALA's side effects can be found at MedlinePlus Visit Here →
Does billing NUCALA require JZ/JW wastage modifiers?
CMS has identified NUCALA(J2182) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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