NUCALA J Code: J2182
Injection, mepolizumab, 1 mg
Q4 2026 Medicare Payment Limit for J2182, effective October 1, 2026: $32.181 per HCPCS billing unit, down 0.3% from $32.281. From CMS's final file.
Drug & Product Overview
About NUCALA
Nucala is a medication aligned to the HCPCS J Code: J2182 for billing, pricing, and reimbursement purposes in the United States. It is an Anti-Eosinophil Asthma drug administered via the subcutaneous route and manufactured by multiple companies.
According to CMS Drug Use Information: This medication is used along with other medications to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma or ongoing lung disease (chronic obstructive pulmonary disease-COPD). Controlling symptoms of breathing problems helps you do your normal activities and decreases time lost from work or school. Mepolizumab is also used to treat certain other immune system disorders (chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome). This medication works by decreasing a certain type of white blood cell (eosinophils). This effect helps reduce swelling (inflammation) of the airways to make breathing easier. It may also help reduce the size of nasal polyps, and lessen symptoms such as runny/stuffy nose, mucus in the throat, loss of smell, facial pain, and tiredness. This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden asthma attacks or breathing problems. If sudden breathing problems occur, use your quick-relief inhaler as prescribed.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 1 of 4 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00173-0881-01 | Nucala | GlaxoSmithKline LLC | 100 | 100 MG / 1 ML |
| •••••-••••-•• Log in to view | NUCALA | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | NUCALA | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | NUCALA | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
NUCALA Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →NUCALA CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96401 | Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic |
CMS has identified Nucala (J2182) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →
NUCALA Medically Unlikely Edits (MUE)
The most billing units of J2182 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
NUCALA Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
Is there an available Nucala billing and coding guide?
Are there any available Nucala patient assistance programs?
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Does billing NUCALA require JZ/JW wastage modifiers?
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