Home › Drug Codes › J Codes › J0775 · XIAFLEX
Updated October 1st, 2026

XIAFLEX J Code: J0775

Injection, collagenase, clostridium histolyticum, 0.01 mg

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Medicare Payment Limit ?
$81.072
up 3.5% since Q3 2026
/ HCPCS billing unitQ3 2026: $78.299
APC Payment Limit ?
$81.072
up 3.5% since Q3 2026
/ HCPCS billing unitQ3 2026: $78.299
ASP ?
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WAC · AWP ?
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NDCs Crosswalked ?
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Drug & Product Overview

HCPCS Descriptor Injection, collagenase, clostridium histolyticum, 0.01 mg
HCPCS Added Date January 1, 2011
Manufacturer Endo USA
Route of Administration Injection
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Kit

About XIAFLEX

Xiaflex is a medication aligned to the HCPCS J Code: J0775 for billing, pricing, and reimbursement purposes in the United States. It is an Orthopedic drug administered via the injection route and manufactured by Endo USA.

According to CMS Drug Use Information: This medication is used to treat certain conditions (Dupuytren's contracture, Peyronie's disease) that are caused by a certain protein (collagen) in your body. Collagen is a tough and strong substance and is found in the knots/cords of the hand in Dupuytren's contracture or plaques in the penis in Peyronie's disease. Collagenase is a substance (enzyme) that breaks down the collagen in these knots/cords/plaques.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
66887-0003-01 Xiaflex Endo USA, Inc. 90 Kit
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XIAFLEX Pricing & Reimbursement

J0775 Private Payer Reimbursement
$75.96 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q4 2026

XIAFLEX CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
20527 Injection, enzyme (e.g., collagenase), palmar fascial cord (i.e., Dupuytren's contracture).
JW / JZ modifiers apply

CMS has identified Xiaflex (J0775) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

XIAFLEX Medically Unlikely Edits (MUE)

The most billing units of J0775 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.01 mg.

Practitioner Office & Hospital Outpatient
180 units / day
= 1.8 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

XIAFLEX Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Dupuytren's contracture Peyronie's disease

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Frequently Asked Questions

Is there an available Xiaflex billing and coding guide?
Billing and coding information for XIAFLEX can be found through Endo USA. Visit Here →
Are there any available Xiaflex patient assistance programs?
XIAFLEX patient assistance information can be found through Endo Pharmaceuticals. Visit Here →
Where can I find Xiaflex prescribing information?
XIAFLEX prescribing information can be found at the link below: Visit Here →
Where can I find Xiaflex side effect information?
Information regarding XIAFLEX's side effects can be found at MedlinePlus Visit Here →
Does billing XIAFLEX require JZ/JW wastage modifiers?
CMS has identified XIAFLEX(J0775) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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