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Updated July 1st, 2026

HYALGAN J Code: J7321

Hyaluronan or derivative, hyalgan, supartz or visco-3, for intra-articular injection, per dose

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Q4 2026 Medicare Payment Limit for J7321, effective October 1, 2026: $69.868 per HCPCS billing unit, down 0.6% from $70.282. From CMS's final file.

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Medicare Payment Limit ?
$70.282
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
4
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Drug & Product Overview

HCPCS Descriptor Hyaluronan or derivative, hyalgan, supartz or visco-3, for intra-articular injection, per dose
HCPCS Added Date January 1, 2008
Manufacturer Multiple Manufacturers
Route of Administration Injection
Generic Status Multi-Source; Generic

About HYALGAN

Hyalgan is a medication aligned to the HCPCS J Code: J7321 for billing, pricing, and reimbursement purposes in the United States. It is an Orthopedic drug administered via the injection route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to treat knee pain in patients with joint inflammation (osteoarthritis). It is usually used in patients who have not responded to other treatments such as acetaminophen, exercise, or physical therapy. Hyaluronate (also known as hyaluronan) is similar to a substance that occurs naturally in the joints. It may work by acting as a lubricant and shock absorber in the joint, helping the knee to move smoothly, thereby lessening pain.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
89122-0724-12 Hyalgan Fidia Pharma USA Inc 1 20 MG / 2 ML
89122-0724-20 Hyalgan Fidia Pharma USA Inc 1 20 MG / 2 ML
89130-4444-01 Supartz FX Bioventus Llc 1 25 MG / 2.5 ML
50016-0957-21 Visco-3 Zimmer Biomet 3 25 MG / 2.5 ML
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HYALGAN Pricing & Reimbursement

J7321 Private Payer Reimbursement
$73.53 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

HYALGAN CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
20610 Arthrocentesis, aspiration and/or injection, major joint or bursa (eg, shoulder, hip, knee, subacromial bursa); without ultrasound guidance
20611 Arthrocentesis, aspiration and/or injection into a joint or bursa (eg, subacromial bursa), under ultrasound guidance with permanent recording and reporting.
Not on the CMS JW / JZ list

CMS does not include Hyalgan (J7321) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7321. Wastage billing guide →

HYALGAN Medically Unlikely Edits (MUE)

The most billing units of J7321 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 dose.

Practitioner Office & Hospital Outpatient
2 units / day
Same limit in both settings

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

HYALGAN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Osteoarthritis of the knee

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Frequently Asked Questions

Is there an available Hyalgan billing and coding guide?
Billing and coding information for HYALGAN can be found through Multiple Manufacturers. Visit Here →
Are there any available Hyalgan patient assistance programs?
HYALGAN patient assistance information can be found through Multiple Manufacturers. Visit Here →
Where can I find Hyalgan prescribing information?
Our team is still working to identify a prescribing information source for HYALGAN
Where can I find Hyalgan side effect information?
Our team has not yet identified a source of side effects information for HYALGAN. Please check back in a few weeks.
Does billing HYALGAN require JZ/JW wastage modifiers?
CMS does not include HYALGAN (J7321) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7321. For more information, visit the link below.

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J0775XIAFLEXInjection, collagenase, clostridium histolyticum, 0.01 mgEndo USAAdded January 1, 2011J3301KENALOG-10Injection, triamcinolone acetonide, not otherwise specified, 10 mgMultiple ManufacturersAdded January 1, 1991J3304ZILRETTAInjection, triamcinolone acetonide, preservative-free, extended-release, microsphere formulation, 1 mgPacira PharmaceuticalsAdded January 1, 2019J7318DurolaneHyaluronan or derivative, durolane, for intra-articular injection, 1 mgBioventusAdded January 1, 2019J7320GENVISC 850Hyaluronan or derivitive, genvisc 850, for intra-articular injection, 1 mgOrthogenrxAdded January 1, 2017J7322HYMOVISHyaluronan or derivative, hymovis or hymovis one, for intra-articular injection, 1 mgFidia PharmaAdded January 1, 2017J7323EuflexxaHyaluronan or derivative, euflexxa, for intra-articular injection, per doseFerring PharmaceuticalsAdded January 1, 2008J7324OrthosviscHyaluronan or derivative, orthovisc, for intra-articular injection, per doseDepuy MitekAdded January 1, 2008J7325SynviscHyaluronan or derivative, synvisc or synvisc-one, for intra-articular injection, 1 mgGenzymeAdded January 1, 2010J7326Gel-OneHyaluronan or derivative, gel-one, for intra-articular injection, per doseZimmerAdded January 1, 2012