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Updated July 1st, 2026

Synvisc J Code: J7325

Hyaluronan or derivative, synvisc or synvisc-one, for intra-articular injection, 1 mg

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Q4 2026 Medicare Payment Limit for J7325, effective October 1, 2026: $6.011 per HCPCS billing unit, down 0.1% from $6.018. From CMS's final file.

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Medicare Payment Limit ?
$6.018
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$6.018
/ HCPCS billing unit · APC 0874
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
2
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Drug & Product Overview

HCPCS Descriptor Hyaluronan or derivative, synvisc or synvisc-one, for intra-articular injection, 1 mg
HCPCS Added Date January 1, 2010
Manufacturer Genzyme
Route of Administration Injection
Generic Status Single-Source; Branded

About Synvisc

Synvisc is a medication aligned to the HCPCS J Code: J7325 for billing, pricing, and reimbursement purposes in the United States. Classified under Orthopedic, it is administered via the injection route and manufactured by Genzyme.

According to CMS Drug Use Information: This medication is used to treat knee pain in patients with joint inflammation (osteoarthritis). It is usually used in patients who have not responded to other treatments such as acetaminophen, exercise, or physical therapy. Hyaluronate (also known as hyaluronan) is similar to a substance that occurs naturally in the joints. It may work by acting as a lubricant and shock absorber in the joint, helping the knee to move smoothly, thereby lessening pain.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
58468-0090-01 Synvisc Genzyme Corporation 48 16 MG / 2 ML
58468-0090-03 SynviscOne Genzyme Corporation 48 48 MG / 6 ML
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Synvisc Pricing & Reimbursement

J7325 Private Payer Reimbursement
$7.69 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Synvisc CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
20610 Arthrocentesis, aspiration and/or injection, major joint or bursa (eg, shoulder, hip, knee, subacromial bursa); without ultrasound guidance
20611 Arthrocentesis, aspiration and/or injection into a joint or bursa (eg, subacromial bursa), under ultrasound guidance with permanent recording and reporting.
Not on the CMS JW / JZ list

CMS does not include Synvisc (J7325) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7325. Wastage billing guide →

Synvisc Medically Unlikely Edits (MUE)

The most billing units of J7325 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient
96 units / day
= 96 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

Synvisc Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Osteoarthritis of the knee

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Frequently Asked Questions

Is there an available Synvisc billing and coding guide?
Billing and coding information for Synvisc can be found through Genzyme. Visit Here →
Are there any available Synvisc patient assistance programs?
Synvisc patient assistance information can be found through Genzyme. Visit Here →
Where can I find Synvisc prescribing information?
Synvisc prescribing information can be found at the link below: Visit Here →
Where can I find Synvisc side effect information?
Our team has not yet identified a source of side effects information for Synvisc. Please check back in a few weeks.
Does billing Synvisc require JZ/JW wastage modifiers?
CMS does not include Synvisc (J7325) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7325. For more information, visit the link below.

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