TYRUKO Q Code: Q5134

Drug & Product Overview

HCPCS Descriptor Injection, natalizumab-sztn (tyruko), biosimilar, 1 mg

HCPCS Added Date April 1, 2024

Manufacturer Sandoz

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection

About TYRUKO

Tyruko is a medication aligned to the HCPCS Q Code: Q5134 for billing, pricing, and reimbursement purposes in the United States. Classified under Immunology, it is administered via the intravenous route and manufactured by Sandoz.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Package	Manufacturer	HCPCS Units	WAC	AWP
61314-0543-94	300 MG / 15 ML Tyruko Intravenous Injection 300 MG/15ML - 1 VIAL, SINGLE-DOSE in 1 CARTON (61314-543-94) / 15 mL in 1 VIAL, SINGLE-DOSE	Sandoz Inc	300	$7,103.38 $23.678 / unit	$8,524.06 $28.414 / unit

Effective 10/20/25 (WAC & AWP)

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TYRUKO Pricing & Reimbursement

Q5134 Private Payer Reimbursement

$23.74 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

NDC Package

HCPCS Units

Markup / Markdown

%

Common:

Estimates only. Payer reimbursement varies by contract, site of care, and sequestration.

Estimated Reimbursement

Natalizumab Biosimilar Information:

TYRUKO Approval Date: August 24, 2023

Product Name	HCPCS Code	Active Ingredient	BLA Type
Tysabri	J2323	Natalizumab	351(a) Originator Product
Tyruko	Q5134	Natalizumab	351(k) Biosimilar

TYRUKO CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

TYRUKO Medically Unlikely Edits (MUE)

The most billing units of Q5134 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 300 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

TYRUKO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Crohn's Disease Multiple Sclerosis

Drug Class

Integrin Receptor Antagonist [EPC]Integrin Receptor Antagonists [MoA]

Frequently Asked Questions

Is there an available TYRUKO billing and coding guide?

We have not identified a manufacturer-published billing and coding guide for TYRUKO

Are there any available TYRUKO patient assistance programs?

Our team has not identified a source of patient assistance information for TYRUKO

Where can I find prescribing information?

TYRUKO prescribing information can be found at the link below: Visit Here →

Where can I find TYRUKO side effect information?

Our team has not yet identified a source of side effect information for TYRUKO.

Does billing TYRUKO require JZ/JW wastage modifiers?

CMS does not include TYRUKO (Q5134) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q5134. For more information, visit the link below.

About BuyandBill.com:

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