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Updated July 1st, 2026

YESINTEK Q Code: Q5100

Injection, ustekinumab-kfce (yesintek), biosimilar, 1 mg

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Q4 2026 Medicare Payment Limit for Q5100, effective October 1, 2026: $3.08 per HCPCS billing unit, down 6.4% from $3.29. From CMS's final file.

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Medicare Payment Limit ?
$3.29
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$3.29
/ HCPCS billing unit · APC 0869
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
4
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Self-Administered Drug Exclusion 7 Medicare Administrative Contractors list Q5100 as usually self-administered and exclude it from Part B coverage in their jurisdictions. Check the article for your MAC before billing: CGS, First Coast, Noridian (A53032), Noridian (A53033), Novitas, Palmetto, Wellpoint Federal, WPS · All SAD lists →

Drug & Product Overview

HCPCS Descriptor Injection, ustekinumab-kfce (yesintek), biosimilar, 1 mg
HCPCS Added Date July 1, 2025
Manufacturer Biocon Biologics Inc
Route of Administration Intravenous, Subcutaneous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution | Solution

About YESINTEK

Yesintek is a medication aligned to the HCPCS Q Code: Q5100 for billing, pricing, and reimbursement purposes in the United States. It is an Immunology drug administered via the intravenous or subcutaneous routes and manufactured by Biocon Biologics Inc.

According to CMS Drug Use Information: Ustekinumab is used to treat plaque psoriasis, a certain type of arthritis (psoriatic arthritis), or certain bowel conditions (Crohn's disease, ulcerative colitis). It works by blocking certain natural proteins in your body (interleukin-12 and interleukin-23) that cause inflammation (swelling) in these conditions. Ustekinumab does not cure these diseases, but helps to lessen symptoms of the disease. It can help to decrease the amount of plaques in plaque psoriasis, decrease the number of swollen/painful joints in psoriatic arthritis, and decrease symptoms such as abdominal pain/cramping and diarrhea in Crohn's disease and ulcerative colitis. This monograph is about the following ustekinumab products: ustekinumab, ustekinumab-aauz, ustekinumab-aekn, ustekinumab-auub, ustekinumab-hmny, ustekinumab-kfce, ustekinumab-srlf, ustekinumab-stba, ustekinumab-ttwe.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
83257-0023-41 Yesintek Biocon Biologics Inc. 45 45 MG / 0.5 ML
83257-0024-11 Yesintek Biocon Biologics Inc. 45 45 MG / 0.5 ML
83257-0025-41 Yesintek Biocon Biologics Inc. 90 90 MG / 1 ML
83257-0026-11 Yesintek Biocon Biologics Inc. 130 130 MG / 26 ML
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YESINTEK Pricing & Reimbursement

Q5100 Private Payer Reimbursement
$25.28 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Ustekinumab Biosimilar Information:

YESINTEK Approval Date: November 29, 2024

Product Name HCPCS Code Active Ingredient BLA Type
Stelara J3358 Ustekinumab 351(a) Originator Product
Wezlana Q5137 Ustekinumab 351(k) Interchangeable
Wezlana Q5138 Ustekinumab 351(k) Interchangeable
Selarsdi Q9998 Ustekinumab 351(k) Interchangeable
Pyzchiva Q9996 Ustekinumab 351(k) Interchangeable
Pyzchiva Q9997 Ustekinumab 351(k) Interchangeable
Otulfi Q9999 Ustekinumab 351(k) Interchangeable
Imuldosa Q5098 Ustekinumab 351(k) Interchangeable
Yesintek Q5100 Ustekinumab 351(k) Interchangeable
Steqeyma Q5099 Ustekinumab 351(k) Interchangeable
Starjemza Q5164 Ustekinumab 351(k) Interchangeable

YESINTEK CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96401 Login for More Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic Login for More
Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

YESINTEK Medically Unlikely Edits (MUE)

The most billing units of Q5100 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient
520 units / day
= 520 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

YESINTEK Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Crohn's Disease Plaque Psoriasis Psoriatic Arthritis Ulcerative Colitis
Drug Class
Interleukin-12 Antagonist [EPC]Interleukin-12 Antagonists [MoA]Interleukin-23 Antagonist [EPC]Interleukin-23 Antagonists [MoA]

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Frequently Asked Questions

Is there an available YESINTEK billing and coding guide?
Billing and coding information for YESINTEK can be found through Biocon Biologics Inc. Visit Here →
Are there any available YESINTEK patient assistance programs?
YESINTEK patient assistance information can be found through Biocon Biologics Inc. Visit Here →
Where can I find YESINTEK prescribing information?
YESINTEK prescribing information can be found at the link below. Visit Here →
Where can I find YESINTEK side effect information?
We have not identified a source of side effect information for YESINTEK.
Does billing YESINTEK require JZ/JW wastage modifiers?
CMS does not include YESINTEK (Q5100) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q5100. For more information, visit the link below.

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Related Drug Codes

Explore billing, coding, and pricing for drugs related to YESINTEK.

J3358STELARAUstekinumab, for intravenous injection, 1 mgJanssenAdded January 1, 2018J3357STELARAUstekinumab, for subcutaneous injection, 1 mgJanssenAdded January 1, 2011Q5098IMULDOSAInjection, ustekinumab-srlf (imuldosa), biosimilar, 1 mgAccordAdded July 1, 2025Q5099STEQEYMAInjection, ustekinumab-stba (steqeyma), biosimilar, 1 mgCelltrion USAAdded July 1, 2025Q5137WezlanaInjection, ustekinumab-auub (wezlana), biosimilar, subcutaneous, 1 mgNuvailaAdded July 1, 2024Q5164StarjemzaInjection, ustekinumab-hmny (starjemza), biosimilar, 1 mgHikmaAdded July 1, 2026Q9996PYZCHIVAInjection, ustekinumab-ttwe (pyzchiva), subcutaneous, 1 mgCordavis LimitedAdded January 1, 2025Q9997PYZCHIVAInjection, ustekinumab-ttwe (pyzchiva), intravenous, 1 mgQuallent PharmaceuticalsAdded January 1, 2025J0139HUMIRAInjection, adalimumab, 1 mgAbbvieAdded January 1, 2025J0717CIMZIAInjection, certolizumab pegol, 1 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)UCB PharmaAdded January 1, 2014