PEMRYDI RTU J Code: J9324

Drug & Product Overview

HCPCS Descriptor Injection, pemetrexed (pemrydi rtu), 10 mg

HCPCS Added Date January 1, 2024

Manufacturer Amneal Pharmaceuticals

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection

About PEMRYDI RTU

Pemrydi RTU is a medication aligned to the HCPCS J Code: J9324 for billing, pricing, and reimbursement purposes in the United States. This Anesthetic medication is administered via the intravenous route and manufactured by Amneal Pharmaceuticals.

According to CMS Drug Use Information: Pemetrexed is used to treat certain types of cancer (such as lung cancer, mesothelioma). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
70121-2453-01	Pemrydi Rtu	Amneal Pharmaceuticals LLC	10	100 MG / 10 ML
70121-2461-01	Pemrydi Rtu	Amneal Pharmaceuticals LLC	50	500 MG / 50 ML

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PEMRYDI RTU Pricing & Reimbursement

J9324 Private Payer Reimbursement

$76.78 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Pemetrexed 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J9292	Avyxa Pharma	Pemetrexed	Injection, pemetrexed dipotassium, 10 mg
J9294	Pfizer	Pemetrexed	Injection, pemetrexed (hospira), not therapeutically equivalent to j9305, 10 mg
J9296	Accord	Pemetrexed	Injection, pemetrexed (accord), not therapeutically equivalent to j9305, 10 mg
J9297	Sandoz	Pemetrexed	Injection, pemetrexed (sandoz), not therapeutically equivalent to j9305, 10 mg
J9304	Generic Code (Multiple Manufacturers)	Pemetrexed	Injection, pemetrexed (pemfexy), 10 mg
J9305 Log in to view
J9314 Log in to view
J9322 Log in to view
J9323 Log in to view
J9324	Amneal Pharmaceuticals	Pemetrexed	Injection, pemetrexed (pemrydi rtu), 10 mg

Log in to view all 10 505(b)(2) codes

PEMRYDI RTU Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 6.77%

Avg. Days to File 5.4days

Avg. Days to Pay 24.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9324 claims analytics on FocalPoint →

PEMRYDI RTU CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

PEMRYDI RTU Medically Unlikely Edits (MUE)

The most billing units of J9324 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

150 units / day

= 1,500 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

PEMRYDI RTU Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Malignant Pleural Mesothelioma Non-Squamous NSCLC

Drug Class

Folate Analog Metabolic Inhibitor [EPC]Folic Acid Metabolism Inhibitors [MoA]

Frequently Asked Questions

Is there an available Pemetrexed billing and coding guide?

Billing and coding information for PEMRYDI RTU can be found through Amneal Biosciences. Visit Here →

Are there any available Pemetrexed patient assistance programs?

PEMRYDI RTU patient assistance information can be found through AMNEAL BIOSCIENCES. Visit Here →

Where can I find Pemetrexed prescribing information?

PEMRYDI RTU prescribing information can be found at the link below: Visit Here →

Where can I find Pemetrexed side effect information?

Information regarding PEMRYDI RTU side effects can be found at MedlinePlus

Does billing PEMRYDI RTU require JZ/JW wastage modifiers?

CMS does not include PEMRYDI RTU (J9324) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9324. For more information, visit the link below.

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