AXTLE J Code: J9292

Drug & Product Overview

HCPCS Descriptor Injection, pemetrexed dipotassium, 10 mg

HCPCS Added Date January 1, 2025

Manufacturer Avyxa Pharma

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About AXTLE

Axtle is a medication aligned to the HCPCS J Code: J9292 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intravenous route and manufactured by Avyxa Pharma.

According to CMS Drug Use Information: Pemetrexed is used to treat certain types of cancer (such as lung cancer, mesothelioma). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Package	Manufacturer	HCPCS Units	WAC	AWP
83831-0131-01	100 MG / 4 ML Axtle Intravenous Injection 100 MG/4ML - 1 VIAL in 1 CARTON (83831-131-01) / 4 mL in 1 VIAL	Avyxa Pharma, LLC	10	$834.04 $83.404 / unit	$1,000.85 $100.085 / unit
83831-0132-01	500 MG / 20 ML Axtle Intravenous Injection 500 MG/20ML - 1 VIAL in 1 CARTON (83831-132-01) / 20 mL in 1 VIAL	Avyxa Pharma, LLC	50	$4,170.21 $83.404 / unit	$5,004.25 $100.085 / unit

Effective 4/1/26 (WAC & AWP)

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AXTLE Pricing & Reimbursement

J9292 Private Payer Reimbursement

$84.14 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

NDC Package

HCPCS Units

Markup / Markdown

%

Common:

Estimates only. Payer reimbursement varies by contract, site of care, and sequestration.

Estimated Reimbursement

Pemetrexed 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J9292	Avyxa Pharma	Pemetrexed	Injection, pemetrexed dipotassium, 10 mg
J9294	Hospira	Pemetrexed	Injection, pemetrexed (hospira), not therapeutically equivalent to j9305, 10 mg
J9296	Accord	Pemetrexed	Injection, pemetrexed (accord), not therapeutically equivalent to j9305, 10 mg
J9297	Sandoz	Pemetrexed	Injection, pemetrexed (sandoz), not therapeutically equivalent to j9305, 10 mg
J9304	Generic Code (Multiple Manufacturers)	Pemetrexed	Injection, pemetrexed (pemfexy), 10 mg
J9305	Generic Code (Multiple Manufacturers)	Pemetrexed	Injection, pemetrexed, not otherwise specified, 10 mg
J9314	Teva	Pemetrexed	Injection, pemetrexed (teva), not therapeutically equivalent to j9305, 10 mg
J9322	Bluepoint Laboratories	Pemetrexed	Injection, pemetrexed (bluepoint), not therapeutically equivalent to j9305, 10 mg
J9323	Pfizer	Pemetrexed	Injection, pemetrexed ditromethamine, 10 mg
J9324	Amneal Biosciences	Pemetrexed	Injection, pemetrexed (pemrydi rtu), 10 mg

AXTLE Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 18.31%

Avg. Days to File 8.7days

Avg. Days to Pay 27.1days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9292 claims analytics on FocalPoint →

AXTLE CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

AXTLE Medically Unlikely Edits (MUE)

The most billing units of J9292 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

150 units / day

= 1,500 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

AXTLE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Malignant Pleural Mesothelioma Non-Squamous NSCLC

Drug Class

Folate Analog Metabolic Inhibitor [EPC]Folic Acid Metabolism Inhibitors [MoA]

Frequently Asked Questions

Is there an available AXTLE billing and coding guide?

Billing and coding information for AXTLE can be found through Avyxa Pharma. Visit Here →

What are the available AXTLE patient assistance programs?

Our team has not identified a source of patient assistance information for AXTLE Visit Here →

Where can I find AXTLE prescribing information?

Prescribing information for AXTLE can be found below. Visit Here →

Where can I find AXTLE side effect information?

Our team has not identified a source of side effect information for AXTLE

Does billing AXTLE require JZ/JW wastage modifiers?

CMS does not include AXTLE (J9292) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9292. For more information, visit the link below.

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