Home Drug Codes Q Codes Q5159 · OSPOMYV AND XBRYK
Updated July 1st, 2026

OSPOMYV AND XBRYK Q Code: Q5159

Injection, denosumab-dssb (ospomyv/xbryk), biosimilar, 1 mg

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Medicare Payment Limit ?
Not published
CMS publishes none for Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
No current ASP
Not available for Q3 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
1
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Drug & Product Overview

HCPCS Descriptor Injection, denosumab-dssb (ospomyv/xbryk), biosimilar, 1 mg
HCPCS Added Date October 1, 2025
Manufacturer Cordavis Limited
Route of Administration Subcutaneous
Generic Status Single-Source; Branded
Dosage Form Injection, Solution

About OSPOMYV AND XBRYK

Ospomyv AND Xbryk is a medication aligned to the HCPCS Q Code: Q5159 for billing, pricing, and reimbursement purposes in the United States. This Osteoporosis medication is administered via the subcutaneous route and manufactured by Cordavis Limited.

Manufacturers, reach out to us to add more information.

NDC Code Information

1 NDC package is crosswalked to Q5159. Package detail is available to logged-in subscribers.

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OSPOMYV AND XBRYK Pricing & Reimbursement

Q5159 Private Payer Reimbursement
$16.27 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Denosumab Biosimilar Information:

OSPOMYV AND XBRYK Approval Date: February 13, 2025

Product Name HCPCS Code Active Ingredient BLA Type
Prolia J0897 Denosumab 351(a) Originator Product
Jubbonti and Wyost Q5136 Denosumab 351(k) Interchangeable
Ospomyv and Xbryk Q5159 Denosumab 351(k) Interchangeable
Stoboclo and Osenvelt Q5157 Denosumab 351(k) Interchangeable
Bomyntra and Conexxence Q5158 Denosumab 351(k) Interchangeable
Bildyos and Bilprevda Q5162 Denosumab 351(k) Interchangeable
Aukelso and Bosaya Q5161 Denosumab 351(k) Interchangeable
Enoby and Xtrenbo Q5167 Denosumab 351(k) Interchangeable
Osvyrti and Jubereq Q5166 Denosumab 351(k) Interchangeable
Oziltus Q5165 Denosumab 351(k) Interchangeable
Boncresa Q5171 Denosumab 351(k) Interchangeable
Ponlimsi Q5173 Denosumab 351(k) Interchangeable

OSPOMYV AND XBRYK CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

OSPOMYV AND XBRYK Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Bone loss in men receiving androgen deprivation therapy for prostate cancer Bone loss in women receiving adjuvant aromatase inhibitor therapy for breast cancer Glucocorticoid-induced osteoporosis Men with osteoporosis at high risk for fracture Postmenopausal women with osteoporosis at high risk for fracture
Drug Class
RANK Ligand Blocking Activity [MoA]RANK Ligand Inhibitor [EPC]

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Frequently Asked Questions

Is there an available Ospomyv And Xbryk billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for Ospomyv And Xbryk.
Are there any available Ospomyv And Xbryk patient assistance programs?
Our team has not identified a manufacturer-published source of patient assitance information for Ospomyv And Xbryk.
Where can I find Ospomyv and Xbryk prescribing information?
Ospomyv And Xbryk prescribing information can be found through the link below. Visit Here →
Where can I find Ospomyv And Xbryk side effect information?
Ospomyv And Xbryk side effect information can be found at the link below. Visit Here →
Does billing Ospomyv And Xbryk require wastage modifiers?
CMS does not include OSPOMYV AND XBRYK (Q5159) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q5159. For more information, visit the link below.

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