CONEXXENCE Q Code: Q5158
Injection, denosumab-bnht (bomyntra/conexxence), biosimilar, 1 mg
Q4 2026 Medicare Payment Limit for Q5158, effective October 1, 2026: $28.702 per HCPCS billing unit, down 0.4% from $28.818. From CMS's final file.
Drug & Product Overview
About CONEXXENCE
Conexxence is a medication aligned to the HCPCS Q Code: Q5158 for billing, pricing, and reimbursement purposes in the United States. Classified under Osteoporosis, it is administered via the subcutaneous route and manufactured by Fresenius Kabi.
According to CMS Drug Use Information: Denosumab is used to treat bone loss (osteoporosis) in people who have a high risk of getting fractures. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases after menopause (in women), as you age, if someone in your family has osteoporosis, or if you take certain medications (such as prednisone) for long periods. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures). Denosumab belongs to a class of drugs called monoclonal antibodies. It prevents certain cells in the body (osteoclasts) from breaking down bone. This monograph is about the following denosumab products: denosumab, denosumab-bbdz, denosumab-bmwo, denosumab-bnht, denosumab-desu, denosumab-dssb, denosumab-kyqq, denosumab-nxxp, and denosumab-qbde.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. The list of NDCs below is not exhaustive.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 65219-0668-01 | Conexxence | Fresenius Kabi USA, LLC | 60 | 60 MG / 1 ML |
| 65219-0670-01 | Bomyntra | Fresenius Kabi USA, LLC | 120 | 119 MG / 1.7 ML |
| 65219-0672-01 | Bomyntra | Fresenius Kabi USA, LLC | 120 | 119 MG / 1.7 ML |
CONEXXENCE Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →Denosumab Biosimilar Information:
CONEXXENCE Approval Date: March 25, 2025
| Product Name | HCPCS Code | Active Ingredient | BLA Type |
|---|---|---|---|
| Prolia | J0897 | Denosumab | 351(a) Originator Product |
| Jubbonti and Wyost | Q5136 | Denosumab | 351(k) Interchangeable |
| Ospomyv and Xbryk | Q5159 | Denosumab | 351(k) Interchangeable |
| Stoboclo and Osenvelt | Q5157 | Denosumab | 351(k) Interchangeable |
| Bomyntra and Conexxence | Q5158 | Denosumab | 351(k) Interchangeable |
| Bildyos and Bilprevda | Q5162 | Denosumab | 351(k) Interchangeable |
| Aukelso and Bosaya | Q5161 | Denosumab | 351(k) Interchangeable |
| Enoby and Xtrenbo | Q5167 | Denosumab | 351(k) Interchangeable |
| Osvyrti and Jubereq | Q5166 | Denosumab | 351(k) Interchangeable |
| Oziltus | Q5165 | Denosumab | 351(k) Interchangeable |
| Boncresa | Q5171 | Denosumab | 351(k) Interchangeable |
| Ponlimsi | Q5173 | Denosumab | 351(k) Interchangeable |
CONEXXENCE Claims Performance
Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.
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CONEXXENCE CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →
CONEXXENCE Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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