Home Drug Codes Q Codes Q5158 · CONEXXENCE
Updated July 1st, 2026

CONEXXENCE Q Code: Q5158

Injection, denosumab-bnht (bomyntra/conexxence), biosimilar, 1 mg

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Q4 2026 Medicare Payment Limit for Q5158, effective October 1, 2026: $28.702 per HCPCS billing unit, down 0.4% from $28.818. From CMS's final file.

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Medicare Payment Limit ?
$28.818
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$28.818
/ HCPCS billing unit · APC 0892
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
3
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Drug & Product Overview

HCPCS Descriptor Injection, denosumab-bnht (bomyntra/conexxence), biosimilar, 1 mg
HCPCS Added Date October 1, 2025
Manufacturer Fresenius Kabi
Route of Administration Subcutaneous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection

About CONEXXENCE

Conexxence is a medication aligned to the HCPCS Q Code: Q5158 for billing, pricing, and reimbursement purposes in the United States. Classified under Osteoporosis, it is administered via the subcutaneous route and manufactured by Fresenius Kabi.

According to CMS Drug Use Information: Denosumab is used to treat bone loss (osteoporosis) in people who have a high risk of getting fractures. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases after menopause (in women), as you age, if someone in your family has osteoporosis, or if you take certain medications (such as prednisone) for long periods. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures). Denosumab belongs to a class of drugs called monoclonal antibodies. It prevents certain cells in the body (osteoclasts) from breaking down bone. This monograph is about the following denosumab products: denosumab, denosumab-bbdz, denosumab-bmwo, denosumab-bnht, denosumab-desu, denosumab-dssb, denosumab-kyqq, denosumab-nxxp, and denosumab-qbde.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
65219-0668-01 Conexxence Fresenius Kabi USA, LLC 60 60 MG / 1 ML
65219-0670-01 Bomyntra Fresenius Kabi USA, LLC 120 119 MG / 1.7 ML
65219-0672-01 Bomyntra Fresenius Kabi USA, LLC 120 119 MG / 1.7 ML
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CONEXXENCE Pricing & Reimbursement

Q5158 Private Payer Reimbursement
$28.97 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Denosumab Biosimilar Information:

CONEXXENCE Approval Date: March 25, 2025

Product Name HCPCS Code Active Ingredient BLA Type
Prolia J0897 Denosumab 351(a) Originator Product
Jubbonti and Wyost Q5136 Denosumab 351(k) Interchangeable
Ospomyv and Xbryk Q5159 Denosumab 351(k) Interchangeable
Stoboclo and Osenvelt Q5157 Denosumab 351(k) Interchangeable
Bomyntra and Conexxence Q5158 Denosumab 351(k) Interchangeable
Bildyos and Bilprevda Q5162 Denosumab 351(k) Interchangeable
Aukelso and Bosaya Q5161 Denosumab 351(k) Interchangeable
Enoby and Xtrenbo Q5167 Denosumab 351(k) Interchangeable
Osvyrti and Jubereq Q5166 Denosumab 351(k) Interchangeable
Oziltus Q5165 Denosumab 351(k) Interchangeable
Boncresa Q5171 Denosumab 351(k) Interchangeable
Ponlimsi Q5173 Denosumab 351(k) Interchangeable

CONEXXENCE Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 23.82%
Avg. Days to File 7.0days
Avg. Days to Pay 24.8days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore Q5158 claims analytics on FocalPoint →
OnPoint Oncology

CONEXXENCE CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

CONEXXENCE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Bone Loss in Men Receiving Androgen Deprivation Therapy for Prostate Cancer Bone Loss in Women Receiving Adjuvant Aromatase Inhibitor Therapy for Breast Cancer Bone Mass Increase in Men with Osteoporosis Giant Cell Tumor of Bone Glucocorticoid-Induced Osteoporosis Hypercalcemia of Malignancy Multiple Myeloma and Bone Metastasis from Solid Tumors Postmenopausal Women with Osteoporosis at High Risk for Fracture
Drug Class
RANK Ligand Blocking Activity [MoA]RANK Ligand Inhibitor [EPC]

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Frequently Asked Questions

Is there an available Conexxence billing and coding guide?
Billing and coding information for CONEXXENCE can be found through Fresenius Kabi USA, LLC. Visit Here →
Are there any available Conexxence patient assistance programs?
CONEXXENCE patient assistance information can be found through Fresenius Kabi USA, LLC. Visit Here →
Where can I find Conexxence prescribing information?
Conexxence prescribing information can be found through the link below. Visit Here →
Where can I find Conexxence side effect information?
Conexxence side effect information can be found at the link below. Visit Here →
Does billing Conexxence require wastage modifiers?
CMS does not include CONEXXENCE (Q5158) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q5158. For more information, visit the link below.

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