OCTREOTIDE ACETATE J Code: J2354
Injection, octreotide, non-depot form for subcutaneous or intravenous injection, 25 mcg
Q4 2026 Medicare Payment Limit for J2354, effective October 1, 2026: $0.574 per HCPCS billing unit, down 3.7% from $0.596. From CMS's final file.
Drug & Product Overview
About OCTREOTIDE ACETATE
Octreotide Acetate is a medication aligned to the HCPCS J Code: J2354 for billing, pricing, and reimbursement purposes in the United States. Classified under Growth Disorder, it is administered via the intravenous or subcutaneous routes and manufactured by multiple companies.
According to CMS Drug Use Information: Octreotide is used to treat severe watery diarrhea and sudden reddening of the face and neck caused by certain types of tumors (such as carcinoid tumors, vasoactive intestinal peptide tumors) that are found usually in the intestines and pancreas. The symptoms occur when these tumors make too much of certain natural substances (hormones). This medication works by blocking the production of these hormones. By decreasing watery diarrhea, octreotide helps to reduce the loss of body fluids and minerals. Octreotide is also used to treat a certain condition (acromegaly) that occurs when the body makes too much of a certain natural substance called growth hormone. Treating acromegaly helps reduce the risk of serious problems such as diabetes and heart disease. Octreotide works by decreasing how much growth hormone your body makes. This drug is not a cure for these conditions. This medication is usually used with other treatment (such as surgery, radiation, other drugs).
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 51 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00078-0180-01 | Sandostatin | Novartis Pharmaceuticals Corporation | 20 | 50 MCG / 1 ML |
| 00641-6174-10 | Octreotide Acetate | Hikma Pharmaceuticals USA Inc. | 20 | 50 MCG / 1 ML |
| 23155-0685-31 | Octreotide Acetate | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 40 | 1000 MCG / 5 ML |
| 25021-0451-01 | Octreotide Acetate | Sagent Pharmaceuticals | 20 | 50 MCG |
| 63323-0376-01 | Octreotide | Fresenius Kabi USA, LLC | 40 | 100 MCG / 1 ML |
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OCTREOTIDE ACETATE Pricing & Reimbursement
National median reimbursement across major commercial payers.
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OCTREOTIDE ACETATE CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96365 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour |
| 96366 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure) |
| 96372 Login for More | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More |
| 96374 Login for More | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug Login for More |
CMS does not include Octreotide Acetate (J2354) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2354. Wastage billing guide →
OCTREOTIDE ACETATE Medically Unlikely Edits (MUE)
The most billing units of J2354 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 25 mcg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
OCTREOTIDE ACETATE Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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