KYPROLIS J Code: J9047

Drug & Product Overview

HCPCS Descriptor Injection, carfilzomib, 1 mg

HCPCS Added Date January 1, 2014

Manufacturer Amgen

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About KYPROLIS

Kyprolis is a medication aligned to the HCPCS J Code: J9047 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology, it is administered via the intravenous route and manufactured by Amgen.

According to CMS Drug Use Information: This medication is used to treat a certain type of cancer (multiple myeloma). It works by helping to slow the growth and spread of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 6 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
76075-0101-01	Kyprolis	Onyx Pharmaceuticals, Inc.	60	60 MG / 30 ML
76075-0101-21	Kyprolis	Onyx Pharmaceuticals, Inc.	60	60 MG / 30 ML
76075-0102-01	Kyprolis	Onyx Pharmaceuticals, Inc.	30	30 MG / 15 ML
76075-0102-21	Kyprolis	Onyx Pharmaceuticals, Inc.	30	30 MG / 15 ML
76075-0103-01	Kyprolis	Onyx Pharmaceuticals, Inc.	10	10 MG / 5 ML
•••••-••••-•• Log in to view	KYPROLIS

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KYPROLIS Pricing & Reimbursement

J9047 Private Payer Reimbursement

$57.57 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

KYPROLIS Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 8.66%

Avg. Days to File 7.2days

Avg. Days to Pay 23.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9047 claims analytics on FocalPoint →

KYPROLIS CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Kyprolis (J9047) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

KYPROLIS Medically Unlikely Edits (MUE)

The most billing units of J9047 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

210 units / day

= 210 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

KYPROLIS Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Relapsed or Refractory Multiple Myeloma

Drug Class

Proteasome Inhibitor [EPC]Proteasome Inhibitors [MoA]

Frequently Asked Questions

Is there an available Kyprolis billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for KYPROLIS.

Are there any available Kyprolis patient assistance programs?

KYPROLIS patient assistance information can be found through Amgen. Visit Here →

Where can I find Kyprolis prescribing information?

KYPROLIS prescribing information can be found at the link below: Visit Here →

Where can I find Kyprolis side effect information?

Information regarding KYPROLIS's side effects can be found at MedlinePlus Visit Here →

Does billing KYPROLIS require JZ/JW wastage modifiers?

CMS has identified KYPROLIS(J9047) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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