SARCLISA J Code: J9227

Drug & Product Overview

HCPCS Descriptor Injection, isatuximab-irfc, 10 mg

HCPCS Added Date October 1, 2020

Manufacturer Multiple Manufacturers

Route of Administration Intravenous, Subcutaneous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection, Solution | Injection, Solution, Concentrate

About SARCLISA

Sarclisa is a medication aligned to the HCPCS J Code: J9227 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology, it is administered via the intravenous or subcutaneous routes and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to treat a certain type of cancer (multiple myeloma). Isatuximab belongs to a class of drugs known as monoclonal antibodies. It works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 3 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00024-0654-01	Sarclisa	Sanofi-Aventis U.S. LLC	10	100 MG / 5 ML
00024-0656-01	Sarclisa	Sanofi-Aventis U.S. LLC	50	500 MG / 25 ML
•••••-••••-•• Log in to view	SARCLISA

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SARCLISA Pricing & Reimbursement

J9227 Private Payer Reimbursement

$86.78 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

SARCLISA Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 16.52%

Avg. Days to File 10.1days

Avg. Days to Pay 26.1days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9227 claims analytics on FocalPoint →

SARCLISA CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Sarclisa (J9227) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

SARCLISA Medically Unlikely Edits (MUE)

The most billing units of J9227 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

150 units / day

= 1,500 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

SARCLISA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Multiple myeloma Newly diagnosed multiple myeloma Relapsed or refractory multiple myeloma

Drug Class

AntibodiesMonoclonal [CS]CD38-directed Antibody Interactions [MoA]CD38-directed Cytolytic Antibody [EPC]

Frequently Asked Questions

Is there an available Sarclisa billing and coding guide?

Billing and coding information for SARCLISA can be found through Sanofi. Visit Here →

Are there any available Sarclisa patient assistance programs?

SARCLISA patient assistance information can be found through Sanofi. Visit Here →

Where can I find Sarclisa prescribing information?

SARCLISA prescribing information can be found at the link below: Visit Here →

Where can I find Sarclisa side effect information?

Information regarding SARCLISA's side effects can be found at MedlinePlus Visit Here →

Does billing SARCLISA require JZ/JW wastage modifiers?

CMS has identified SARCLISA(J9227) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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